Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Ann Hematol. 2010 Sep;89(9):873-6. doi: 10.1007/s00277-010-0957-6. Epub 2010 Apr 20.
Previous studies have demonstrated a modest association between smoking and leukemia particularly for myeloid disorders. Our objective was to examine whether changing trends in cigarette smoking prevalence nationally and within selected states parallel similar trends in mortality from leukemia. Trends in national smoking rates were correlated with trends in leukemia mortality rates obtained from the Centers for Disease Control and Prevention and the Surveillance Epidemiology and End Results registry, respectively. State-specific correlations were assessed from 1984 to 2004 using smoking prevalence data from the Behavioral Risk Factor Surveillance System and leukemia mortality data from National Vital Statistics System. Correlations were computed using the Spearman rank correlation coefficient. Leukemia mortality decreased overall in the United States in parallel with decreased smoking. Analyzed on a state-specific basis, leukemia mortality decreased in states where smoking rates declined markedly but remained unchanged where smoking prevalences were relatively stable. The findings suggest that declining rates of leukemia mortality are associated with changing patterns of smoking behavior.
先前的研究表明，吸烟与白血病之间存在一定的关联，尤其是与骨髓疾病相关。我们的目的是检验全国范围内以及在一些特定州的吸烟流行率的变化趋势是否与白血病死亡率的相似趋势相吻合。通过美国疾病控制与预防中心和监测、流行病学和最终结果登记处，分别将全国吸烟率的趋势与白血病死亡率的趋势进行相关分析。通过行为危险因素监测系统获得的各州具体的吸烟流行率数据和国家生命统计系统的白血病死亡率数据，评估了 1984 年至 2004 年的各州特定相关性。使用斯皮尔曼等级相关系数进行相关性计算。在美国，白血病死亡率总体呈下降趋势，与吸烟率下降相吻合。在那些吸烟率显著下降的州，白血病死亡率呈下降趋势，而在那些吸烟率相对稳定的州，白血病死亡率则保持不变。这些发现表明，白血病死亡率的下降与吸烟行为模式的变化有关。
