Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, India.
Neuroimmunomodulation. 2010;17(5):333-9. doi: 10.1159/000292023. Epub 2010 Apr 17.
The prevalence of tuberculous meningitis (TBM) is very high in developing areas of the world. Inflammation and cytokine patterns produced by T lymphocytes play an important role in susceptibility to infections. The inflammatory response and production of cytokines in the cerebrospinal fluid (CSF) of patients with TBM are well documented. Conversely, little is known about the role of pro- and anti-inflammatory cytokines in the CSF of TBM patients. The goal of the present study was to estimate the level of proinflammatory cytokine and anti-inflammatory cytokine levels in CSF samples from TBM patients.
To study this, in vivo levels of IL-2 and IFN-gamma (proinflammatory cytokines), and IL-10 (anti-inflammatory cytokine) in the CSF of 60 adult TBM patients and 50 age- and sex-matched non-TBM controls were measured. These cytokines were estimated in the CSF of TBM patients before and after starting treatment.
High levels of proinflammatory cytokines as compared to anti-inflammatory cytokines were found in TBM patients before treatment. However, CSF samples from TBM patients after treatment showed elevated levels of anti-inflammatory and low levels of proinflammatory cytokines.
We hypothesize that an increase in anti-inflammatory cytokines during treatment may indicate a favorable response.
在世界发展中地区，结核性脑膜炎（TBM）的患病率非常高。T 淋巴细胞产生的炎症和细胞因子模式在易感性方面起着重要作用。TBM 患者脑脊液中的炎症反应和细胞因子产生已有充分记录。相反，对于 TBM 患者脑脊液中促炎和抗炎细胞因子的作用知之甚少。本研究的目的是评估 TBM 患者脑脊液中促炎细胞因子和抗炎细胞因子水平。
为了研究这一点，我们测量了 60 名成年 TBM 患者和 50 名年龄和性别匹配的非 TBM 对照者脑脊液中 IL-2 和 IFN-γ（促炎细胞因子）和 IL-10（抗炎细胞因子）的体内水平。在开始治疗之前和之后，我们评估了 TBM 患者脑脊液中的这些细胞因子。
与抗炎细胞因子相比，治疗前 TBM 患者的促炎细胞因子水平较高。然而，TBM 患者治疗后的脑脊液样本显示抗炎细胞因子水平升高，促炎细胞因子水平降低。
我们假设治疗过程中抗炎细胞因子的增加可能表明预后良好。
