Department of Neurology, Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University , Fuzhou, China.
Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou, China.
Microbiol Spectr. 2024 Jan 11;12(1):e0224623. doi: 10.1128/spectrum.02246-23. Epub 2023 Dec 4.
Tuberculous meningitis is a life-threatening infection with high mortality and disability rates. Current diagnostic methods using cerebrospinal fluid (CSF) samples have limited sensitivity and lack predictive biomarkers for evaluating prognosis. This study's findings reveal excessive activation of the immune response during tuberculous meningitis (TBM) infection. Notably, a strong negative correlation was observed between CSF levels of monokine induced by interferon-γ (MIG) and the CSF/blood glucose ratio in TBM patients. MIG also exhibited the highest area under the curve with high sensitivity and specificity. This study suggests that MIG may serve as a novel biomarker for differentiating TBM infection in CSF or serum, potentially leading to improved diagnostic accuracy and better patient outcomes.
结核性脑膜炎是一种危及生命的感染，死亡率和致残率都很高。目前使用脑脊液（CSF）样本的诊断方法灵敏度有限，缺乏用于评估预后的预测生物标志物。本研究的结果表明，结核性脑膜炎（TBM）感染期间免疫反应过度激活。值得注意的是，在 TBM 患者中，干扰素-γ诱导的单因子（MIG）的 CSF 水平与 CSF/血糖比值呈强烈负相关。MIG 还表现出最高的曲线下面积，具有高灵敏度和特异性。本研究表明，MIG 可能作为一种新型生物标志物，用于区分 CSF 或血清中的 TBM 感染，可能会提高诊断准确性和改善患者预后。
