Department of Pathology and Laboratory Medicine, University of Calgary, and Calgary Laboratory Services, 11th Floor, Foothills Medical Center, 1403-29 Street NW, Calgary, Alberta, Canada T2N 2T9.
Int J Gynecol Pathol. 2010 May;29(3):269-72. doi: 10.1097/PGP.0b013e3181c1cbf2.
Endometrial adenocarcinoma presenting with deep venous thrombosis is an exceptional event more typical of extra-mullerian primary tumors. Metastases to the spleen are also unusual in this setting. In addition, primary endometrial adenocarcinoma with signet-ring cell features has been reported only once. This study describes a case of primary endometrial carcinoma with prominent signet-ring cell features that presented in an unusual manner: with bilateral deep vein thromboses and splenic metastases. It is important for clinicians and pathologists to be aware of this entity; it may have an atypical clinical presentation and the histologic features raise a spectrum of differential diagnoses.
以深静脉血栓形成表现的子宫内膜腺癌是一种罕见的现象，更常见于子宫外的原发性肿瘤。在这种情况下，脾脏转移也不常见。此外，具有印戒细胞特征的原发性子宫内膜腺癌仅报告过一次。本研究描述了一例以明显印戒细胞特征为表现的原发性子宫内膜癌，其表现形式不典型：双侧深静脉血栓形成和脾脏转移。临床医生和病理学家了解这种疾病很重要；它可能具有非典型的临床表现，其组织学特征引起一系列鉴别诊断。
