Mooney E E, Robboy S J, Hammond C B, Berchuck A, Bentley R C
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Int J Gynecol Pathol. 1997 Apr;16(2):169-72. doi: 10.1097/00004347-199704000-00014.
Extragenital metastases to the endometrium are unusual, but several histologic features have been suggested as highly suggestive or even pathognomonic for this diagnosis. We report an endometrial carcinoma with a prominent signet-ring cell morphology and a diffusely permeative pattern of infiltration, features that have been reported as indicating an extragenital metastasis. To the best of our knowledge, this is the first reported case of a signet-ring cell carcinoma of the endometrium. Gynecological pathologists should be aware of this entity because of its potential primary of metastatic signet-ring carcinoma to be endometrium.
