Wiłkość Monika, Hauser Joanna, Tomaszewska Marta, Dmitrzak-Weglarz Monika, Skibińska Maria, Szczepankiewicz Aleksandra, Borkowska Alina
Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.
Acta Neurobiol Exp (Wars). 2010;70(1):86-94. doi: 10.55782/ane-2010-1777.
Working memory is an ability to keep information in short-term memory and manipulate them 'on line'. Working memory is also involved in complex frontal executive functions. The role of dopaminergic system in modulating working memory processes in prefrontal cortex is well established. Also the role of serotoninergic receptors is postulated. The purpose of this study was to assess the association between the polymorphisms of dopaminergic (DRD1, DRD3, DRD4, COMT) and serotoninergic (SERT--serotonin transporter, 5HT2A, 5HT2C) genes' polymorphisms and performance on WCST in 200 volunteers from the Polish population. We found the association between DRD1, DRD4, COMT and SERT genes polymorphisms and the performance on WCST. The results obtained in the study indicate that dopaminergic and serotoninergic genes may play a role in modulating the executive function and working memory processes in healthy subjects. The pattern of this influence may be different in males and females. Moreover, the relationship between the efficacy of prefrontal cognitive function and genes polymorphisms may differ between healthy subjects and schizophrenic patients.
工作记忆是一种将信息保持在短期记忆中并“在线”对其进行操作的能力。工作记忆还涉及复杂的额叶执行功能。多巴胺能系统在调节前额叶皮质工作记忆过程中的作用已得到充分证实。血清素能受体的作用也被推测。本研究的目的是评估来自波兰人群的200名志愿者中多巴胺能（DRD1、DRD3、DRD4、COMT）和血清素能（SERT——血清素转运体、5HT2A、5HT2C）基因多态性与威斯康星卡片分类测验（WCST）表现之间的关联。我们发现DRD1、DRD4、COMT和SERT基因多态性与WCST表现之间存在关联。该研究获得的结果表明，多巴胺能和血清素能基因可能在调节健康受试者的执行功能和工作记忆过程中发挥作用。这种影响模式在男性和女性中可能不同。此外，前额叶认知功能的效能与基因多态性之间的关系在健康受试者和精神分裂症患者之间可能存在差异。
