Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA.
Chem Res Toxicol. 2010 Jun 21;23(6):1001-8. doi: 10.1021/tx100056m.
Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.
烟草致癌物和有毒物生物标志物是烟草制品中特定化合物的代谢物或蛋白质或 DNA 加合物。已经开发出并应用了高度可靠的分析方法，主要基于质谱法，这些方法已应用于对许多此类生物标志物的大型研究中。这里提出了一组烟草致癌物和有毒物生物标志物，总结了吸烟者和不吸烟者的典型值。该生物标志物组具有在烟草产品监管的新的和具有挑战性的领域中的应用潜力，并且通过建立暴露于烟草制品的人致癌物和有毒物的摄取和排泄，为癌症预防的合理方法的发展提供了可能性。
