应用烟草致癌物和有毒物生物标志物进行产品监管和癌症预防。
Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.
机构信息
Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA.
出版信息
Chem Res Toxicol. 2010 Jun 21;23(6):1001-8. doi: 10.1021/tx100056m.
Abstract
Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.
摘要
烟草致癌物和有毒物生物标志物是烟草制品中特定化合物的代谢物或蛋白质或 DNA 加合物。已经开发出并应用了高度可靠的分析方法，主要基于质谱法，这些方法已应用于对许多此类生物标志物的大型研究中。这里提出了一组烟草致癌物和有毒物生物标志物，总结了吸烟者和不吸烟者的典型值。该生物标志物组具有在烟草产品监管的新的和具有挑战性的领域中的应用潜力，并且通过建立暴露于烟草制品的人致癌物和有毒物的摄取和排泄，为癌症预防的合理方法的发展提供了可能性。
相似文献
1
Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.应用烟草致癌物和有毒物生物标志物进行产品监管和癌症预防。
Chem Res Toxicol. 2010 Jun 21;23(6):1001-8. doi: 10.1021/tx100056m.
2
Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.致癌性烟草特有亚硝胺的暴露和代谢激活生物标志物
Acc Chem Res. 2016 Jan 19;49(1):106-14. doi: 10.1021/acs.accounts.5b00472. Epub 2015 Dec 17.
3
Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators.烟草致癌物代谢物和 DNA 加合物作为头颈部癌症的生物标志物：潜在的筛查工具和预后指标。
Head Neck. 2012 Mar;34(3):441-7. doi: 10.1002/hed.21705. Epub 2011 May 25.
4
Biomarkers of induced active and passive smoking damage.主动和被动吸烟损害的生物标志物。
Int J Environ Res Public Health. 2009 Mar;6(3):874-88. doi: 10.3390/ijerph6030874. Epub 2009 Feb 26.
5
Tobacco and cancer: approaches using carcinogen biomarkers and chemoprevention.烟草与癌症：使用致癌物生物标志物及化学预防的方法
Ann N Y Acad Sci. 1997 Dec 29;833:91-111. doi: 10.1111/j.1749-6632.1997.tb48596.x.
6
Environmental and chemical carcinogenesis.环境与化学致癌作用
Semin Cancer Biol. 2004 Dec;14(6):473-86. doi: 10.1016/j.semcancer.2004.06.010.
7
Assessment of tobacco specific nitrosamines (TSNAs) in oral fluid as biomarkers of cancer risk: A population-based study.评估口腔液中烟草特异性亚硝胺（TSNAs）作为癌症风险生物标志物：一项基于人群的研究。
Environ Res. 2016 Nov;151:635-641. doi: 10.1016/j.envres.2016.08.036. Epub 2016 Sep 10.
8
Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act.与《家庭吸烟预防和烟草控制法》下的烟草产品标准制定相关的研究机会。
Nicotine Tob Res. 2012 Jan;14(1):18-28. doi: 10.1093/ntr/ntq216. Epub 2011 Jan 10.
9
Carcinogen metabolism in human lung tissues and the effect of tobacco smoking: results from a case--control multicenter study on lung cancer patients.人类肺组织中的致癌物代谢及吸烟的影响：一项针对肺癌患者的病例对照多中心研究结果
Environ Health Perspect. 1992 Nov;98:119-24. doi: 10.1289/ehp.9298119.
10
Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.减少吸烟对一种烟草特异性肺致癌物摄取的影响。
J Natl Cancer Inst. 2004 Jan 21;96(2):107-15. doi: 10.1093/jnci/djh016.
引用本文的文献
1
Chemical Biomarkers of Exposure and Early Damage from Potentially Carcinogenic Airborne Pollutants.潜在致癌性空气污染物暴露及早期损害的化学生物标志物
Ann Cancer Epidemiol. 2019 Sep;3. doi: 10.21037/ace.2019.08.01. Epub 2019 Sep 6.
2
Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults.口服尼古丁袋对吸烟行为和烟草危害暴露的影响：一项针对成年人的随机试点试验。
Tob Control. 2025 Jun 23. doi: 10.1136/tc-2024-059094.
3
Exposure to polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines and incidence of esophageal cancer.多环芳烃、挥发性有机化合物、烟草特异性亚硝胺暴露与食管癌发病风险的关系。
J Natl Cancer Inst. 2024 Mar 7;116(3):379-388. doi: 10.1093/jnci/djad218.
4
Reductions in biomarkers of exposure to selected harmful and potentially harmful constituents following exclusive and partial switching from combustible cigarettes to myblu electronic nicotine delivery systems (ENDS).在完全或部分从可燃香烟切换到 myblu 电子尼古丁输送系统（ENDS）后，选定有害和潜在有害成分的暴露生物标志物的减少。
Intern Emerg Med. 2022 Mar;17(2):397-410. doi: 10.1007/s11739-021-02813-w. Epub 2021 Aug 26.
5
Relationship Between Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol and Lung Cancer Risk in the General Population: A Community-Based Prospective Cohort Study.一般人群中尿4-(甲基亚硝胺基)-1-(3-吡啶基)-1-丁醇与肺癌风险的关系：一项基于社区的前瞻性队列研究。
Front Oncol. 2021 Mar 22;11:611674. doi: 10.3389/fonc.2021.611674. eCollection 2021.
6
Ethnic Differences of Urinary Cadmium in Cigarette Smokers from the Multiethnic Cohort Study.多民族队列研究中吸烟者尿镉的种族差异
Int J Environ Res Public Health. 2021 Mar 6;18(5):2669. doi: 10.3390/ijerph18052669.
7
Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies.代谢物与肺癌风险之间的关联：观察性研究的系统文献综述和荟萃分析
Metabolites. 2020 Sep 5;10(9):362. doi: 10.3390/metabo10090362.
8
Identification and quantification of phenanthrene ortho-quinones in human urine and their association with lipid peroxidation.鉴定和定量人尿液中的菲醌邻醌及其与脂质过氧化的关系。
Environ Pollut. 2020 Nov;266(Pt 1):115342. doi: 10.1016/j.envpol.2020.115342. Epub 2020 Aug 6.
9
Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies.运用烟草、环境和饮食相关生物标志物来了解癌症病因学并评估预防策略。
Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):1904-1919. doi: 10.1158/1055-9965.EPI-19-1356. Epub 2020 Feb 12.
10
Oral Health Effects of Combusted and Smokeless Tobacco Products.燃烧型和无烟烟草制品对口腔健康的影响。
Adv Dent Res. 2019 Oct;30(1):4-10. doi: 10.1177/0022034519872480.
本文引用的文献
1
2
Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.烟草特异性生物标志物和肺癌致癌物 4-(甲基亚硝氨基)-1-(3-吡啶基)-1-丁醇的消除动力学。
Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3421-5. doi: 10.1158/1055-9965.EPI-09-0874.
3
Surveillance methods for identifying, characterizing, and monitoring tobacco products: potential reduced exposure products as an example.监测方法用于识别、描述和监测烟草制品：以潜在减害产品为例。
Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3334-48. doi: 10.1158/1055-9965.EPI-09-0429.
4
Reconciling human smoking behavior and machine smoking patterns: implications for understanding smoking behavior and the impact on laboratory studies.协调人类吸烟行为和机器吸烟模式：对理解吸烟行为和对实验室研究影响的启示。
Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3305-20. doi: 10.1158/1055-9965.EPI-09-1014.
5
Clinical trials methods for evaluation of potential reduced exposure products.评价潜在减害产品的临床试验方法。
Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3143-95. doi: 10.1158/1055-9965.EPI-09-0654.
6
State-specific secondhand smoke exposure and current cigarette smoking among adults - United States, 2008.2008年美国成年人中特定州的二手烟暴露情况及当前吸烟状况
MMWR Morb Mortal Wkly Rep. 2009 Nov 13;58(44):1232-5.
7
A review of human carcinogens--Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish.人类致癌物综述——E部分：烟草、槟榔、酒精、煤烟和咸鱼。
Lancet Oncol. 2009 Nov;10(11):1033-4. doi: 10.1016/s1470-2045(09)70326-2.
8
Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products.一些口服尼古丁替代疗法产品使用者的尿液中存在致癌物N'-亚硝基去甲烟碱。
Cancer Res. 2009 Nov 1;69(21):8236-40. doi: 10.1158/0008-5472.CAN-09-1084. Epub 2009 Oct 20.
9
Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers.测定吸烟人群和不吸烟人群尿液中的烟草特有 N-亚硝胺。
Biomarkers. 2009 Dec;14(8):547-53. doi: 10.3109/13547500903242883.
10
Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers.吸烟者和非吸烟者白细胞中甲醛-DNA加合物水平存在明显差异。
Cancer Res. 2009 Sep 15;69(18):7170-4. doi: 10.1158/0008-5472.CAN-09-1571. Epub 2009 Sep 8.
Zotero 插件