Langen Susanne, Lötscher Patrick, Prost Jean-Christophe, Bovet Cédric, Vögelin Esther, Surke Carsten
Department of Plastic and Hand Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Int Wound J. 2023 Oct 17;21(2). doi: 10.1111/iwj.14425.
Toxic reactions can appear after pressurised flushing of soft tissue with octenidine (OCT) containing disinfectants. Their use for surgical disinfection could complicate the diagnosis of possible contamination. In patients with open lacerations of their hand's subcutaneous tissue samples were taken before and after surgical disinfection with Octenisept® and analysed by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). In 16 out of 20 tissue samples, OCT was detected after disinfection (lower limit of quantification (LLOQ)=10 pg/mL/mg). The concentration of OCT was below the LLOQ, estimation of mean of 0.6 pg/mL/mg (0.22-0.98 pg/mL/mg, 95%-CI) before disinfection and mean of 179.4 pg/mL/mg (13.35-432.0 pg/mL/mg, 95%-CI) after disinfection. This study shows that the disinfection of open wounds with Octenisept® leads to a quantifiable concentration of OCT in open wounds. In cases of suspected OCT-mediated toxic reaction, the use of antiseptics containing OCT should be avoided.
使用含奥替尼啶（OCT）的消毒剂对软组织进行加压冲洗后可能会出现毒性反应。将其用于手术消毒可能会使可能的污染诊断变得复杂。对于手部皮下组织有开放性撕裂伤的患者，在使用Octenisept®进行手术消毒前后采集组织样本，并通过超高效液相色谱-串联质谱法（LC-MS/MS）进行分析。在20个组织样本中，有16个在消毒后检测到了OCT（定量下限（LLOQ）=10 pg/mL/mg）。消毒前OCT浓度低于LLOQ，估计平均值为0.6 pg/mL/mg（0.22 - 0.98 pg/mL/mg，95%置信区间），消毒后平均值为179.4 pg/mL/mg（13.35 - 432.0 pg/mL/mg，95%置信区间）。本研究表明，使用Octenisept®对开放性伤口进行消毒会导致开放性伤口中OCT浓度可量化。在怀疑有OCT介导的毒性反应的情况下，应避免使用含OCT的防腐剂。
