Graduate Program, Federal University of São Paulo (UNIFESP), Rua Napoleão de Barros 715, 4o andar, Vila Clementino, CEP 04024-002 São Paulo, Brazil.
J Tissue Viability. 2010 Nov;19(4):150-8. doi: 10.1016/j.jtv.2010.03.003. Epub 2010 Apr 20.
High-molecular-weight sodium heparin (10,000 IU) has been developed based on studies conducted on burn patients; it has anti-inflammatory, antigenic and anticoagulant properties.
The aim of this paper was to evaluate the effects of topical application of sodium heparin spray on two immunosuppressed patients (a child and a young person) with perineal dermatitis and an immunosuppressed child with second-degree burns.
This is a report of three clinical cases treated in a pediatric hospital. Sodium heparin spray (10,000 IU) was applied at a dose of 4200 IU per percentage of body surface area affected over the hyperemic region. Heparin spray treatment was discontinued after crust formation and wound reepithelialization; essential fatty acid was applied until spontaneous separation of the crust or total wound reepithelialization.
Heparin spray had analgesic, angiogenic and anti-inflammatory effects, and did not require secondary wound closure. Pain control was of fundamental importance to the patients; in the three cases, improvement in analgesia was achieved within 24 h of treatment.
The topical application of heparin spray in patients with perineal dermatitis or superficial second-degree burns demonstrated good tolerability, resulted in good aesthetic outcomes, and reduced pain.
基于对烧伤患者的研究，开发了高分子量肝素钠（10000IU），它具有抗炎、抗原和抗凝作用。
本文旨在评估肝素钠喷雾剂局部应用于会阴皮炎的 2 例免疫抑制患者（1 例儿童和 1 例青年）和 1 例免疫抑制的二度烧伤儿童的效果。
这是一篇在儿科医院治疗的 3 例临床病例报告。在充血区域，按每 1%体表面积 4200IU 的剂量应用肝素钠喷雾剂（10000IU）。在结痂形成和伤口再上皮化后停止肝素喷雾治疗；应用必需脂肪酸直至结痂自然分离或伤口完全再上皮化。
肝素喷雾具有镇痛、血管生成和抗炎作用，无需进行二次伤口闭合。疼痛控制对患者至关重要；在这 3 例患者中，治疗后 24 小时内疼痛得到了改善。
肝素钠喷雾剂局部应用于会阴皮炎或浅二度烧伤患者具有良好的耐受性，可获得良好的美学效果，并减轻疼痛。
