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中欧罗姆族和非罗姆族患者接受诊断性多导睡眠图检查的阻塞性睡眠呼吸暂停的风险因素和严重程度 [已更正]。

Risk factors and severity of obstructive sleep apnoea in central European Roma and non-Roma patients referred for a diagnostic polysomnography [corrected].

机构信息

Department of Respiratory Diseases and Tuberculosis, P. J. Safarik University, L. Pasteur Teaching Hospital, Rastislavova 43, Kosice, Slovakia.

出版信息

Int J Public Health. 2010 Oct;55(5):429-34. doi: 10.1007/s00038-010-0146-3. Epub 2010 Apr 24.

Abstract

OBJECTIVE

Obesity and metabolic syndrome are common among Roma subjects in Slovakia. We hypothesised that Roma subjects are at high risk to suffer from severe obstructive sleep apnoea (OSA).

METHODS

137 non-Roma and 23 Roma subjects referred for a diagnostic polysomnography were consecutively recruited. Overnight polysomnography, anthropometric variables and standard biochemical analyses were analysed.

RESULTS

Obstructive sleep apnoea was diagnosed in 91% Roma and 65% non-Roma subjects (p < 0.001). Roma subjects had higher apnoea-hypopnoea index (AHI) (61.2 ± 7.9 vs. 22.8 ± 2.3 events/h, p < 0.001), lower dip oxygen saturation (56.7 ± 4.9 vs. 79.3 ± 1.3%, p < 0.001), and higher waist circumference as compared to non-Roma subjects (121.3 ± 3.1 vs. 105.2 ± 2.4 cm, p < 0.001). In multiple regression analysis, Roma background (p < 0.001) and waist circumference (p < 0.001) were independent predictors of AHI (R (2) = 0.330). Roma background was associated with significantly higher risk of severe OSA (odds ratio 3.73; 95% confidence interval 1.20-11.65, p = 0.023), independently of age, gender and waist circumference.

CONCLUSIONS

Among subjects referred for polysomnography, Roma background is associated with significantly higher risk of severe OSA. Knowledge of common OSA pattern in Roma patients may help in identifying high risk individuals and guide early therapy of this disease.

摘要

目的

肥胖和代谢综合征在斯洛伐克的罗姆人群中很常见。我们假设罗姆人群患严重阻塞性睡眠呼吸暂停(OSA)的风险很高。

方法

连续招募了 137 名非罗姆人和 23 名罗姆人,这些人因诊断性多导睡眠图而被转介。对整夜多导睡眠图、人体测量学变量和标准生化分析进行了分析。

结果

91%的罗姆人和 65%的非罗姆人被诊断为阻塞性睡眠呼吸暂停(p<0.001)。与非罗姆人相比,罗姆人受试者的睡眠呼吸暂停低通气指数(AHI)更高(61.2±7.9 与 22.8±2.3 事件/小时,p<0.001),脱氧饱和度更低(56.7±4.9 与 79.3±1.3%,p<0.001),腰围也更大(121.3±3.1 与 105.2±2.4 厘米,p<0.001)。多元回归分析显示,罗姆背景(p<0.001)和腰围(p<0.001)是 AHI 的独立预测因子(R (2)为 0.330)。罗姆背景与严重 OSA 的发生风险显著增加相关(比值比 3.73;95%置信区间 1.20-11.65,p=0.023),与年龄、性别和腰围无关。

结论

在接受多导睡眠图检查的患者中,罗姆背景与严重 OSA 的风险显著增加相关。了解罗姆患者常见的 OSA 模式可能有助于识别高危人群,并指导该病的早期治疗。

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