Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Spain.
Antimicrob Agents Chemother. 2010 Jul;54(7):3058-60. doi: 10.1128/AAC.01270-09. Epub 2010 Apr 26.
Forty-four isolates belonging to human pathogenic species of Lichtheimia were tested against nine antifungal agents by using the EUCAST methodology. No remarkable differences were found between the clinical species, although L. ramosa showed slightly higher MICs for all drugs. Amphotericin B was the most active drug. Among azole drugs, posaconazole had the best activity in vitro and voriconazole was inactive. Echinocandins showed activity for some isolates, suggesting a potential role in combination therapy.
采用 EUCAST 方法,对 44 株属于人致病性亮菌属物种的分离株进行了 9 种抗真菌药物的药敏试验。虽然 L. ramosa 对所有药物的 MIC 值略高,但临床分离株之间未见明显差异。两性霉素 B 是最有效的药物。在唑类药物中,泊沙康唑具有最佳的体外活性,而伏立康唑无活性。棘白菌素类药物对一些分离株显示出活性,表明其在联合治疗中有潜在作用。