Li Xiaoming, Lu Xiuying, Chen Yinghui
Department of Otolaryngology-Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050082, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Feb;24(4):149-51.
To study the expression of CD137L in laryngeal carcinoma, and to analyze its clinicopathological significance.
The expression of CD137L in 50 laryngeal carcinoma specimens and 9 normal laryngeal mucous tissues were detected by immunohistochemical staining.
The positive CD137L staining were found in all 50 cases of laryngeal carcinomas (100%), while its staining were negative in normal laryngeal mucous. There was significant difference between two groups (P < 0.01). The positive ratio of CD137L staining had no relationship with the factors such as age, sex and tumor site, while it had significant correlation with the pathological stage, T stage and lymph node metastasis.
The expression of CD137L might play an important role in the development of laryngeal carcinomas.
研究CD137L在喉癌中的表达情况，并分析其临床病理意义。
采用免疫组织化学染色法检测50例喉癌标本及9例正常喉黏膜组织中CD137L的表达。
50例喉癌组织中CD137L染色均呈阳性（100%），而正常喉黏膜组织中CD137L染色呈阴性。两组之间差异有统计学意义（P < 0.01）。CD137L染色阳性率与年龄、性别及肿瘤部位等因素无关，而与病理分期、T分期及淋巴结转移显著相关。
CD137L的表达可能在喉癌的发生发展中起重要作用。
