Li Lianhe, Yue Zhuoli, Feng Xiuling, Liu Jina, Liu Shuhong
Department of Otolaryngology, Affiliated Hospital of Chengde Medical Institute, Chengde, 067000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Aug;23(15):673-5.
To investigate the expression of EMS1 in laryngeal carcinoma and its clinical significance.
The expression of EMS1 protein was measured in 40 samples of, 40 samples of para carcinoma tissues (which were near to cutting margin of laryngeal carcinoma tissue over 0.5 cm), and 20 samples of normal laryngeal mucosa as controls by Flow Cytometer (Epics-XL II).
The quantity and percentage of EMS1 protein expression in laryngeal carcinoma tissues was significantly higher than those in para carcinoma and in normal laryngeal mucosa tissues respectively (P<0.05). There was no significant expression difference between the para carcinoma tissues and normal laryngeal mucosa tissues. There were positive correlation between the expressions of EMS1 protein and metastasis, pathological grade and clinical stage in laryngeal carcinoma. But there were not relationship with patients' clinical classification, tumor size, smoking history, age and sex.
The high expression of EMS1 may contribute to the carcinogenesis and development of laryngeal carcinoma. The expression of EMS1 protein is an important index of judging differentiation, infiltration, metastasis and staging of laryngeal carcinoma.
探讨表皮生长因子受体底物1（EMS1）在喉癌中的表达及其临床意义。
采用流式细胞仪（Epics-XL II）检测40例喉癌组织、40例癌旁组织（距喉癌组织切缘0.5 cm以上）及20例正常喉黏膜组织中EMS1蛋白的表达。
喉癌组织中EMS1蛋白表达量及阳性率分别显著高于癌旁组织和正常喉黏膜组织（P<0.05）。癌旁组织与正常喉黏膜组织之间EMS1蛋白表达差异无统计学意义。喉癌中EMS1蛋白表达与喉癌转移、病理分级及临床分期呈正相关。但与患者临床分型、肿瘤大小、吸烟史、年龄及性别无关。
EMS1高表达可能参与喉癌的发生发展过程。EMS1蛋白表达是判断喉癌分化、浸润、转移及分期的重要指标。
