Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic.
Curr Hypertens Rep. 2010 Feb;12(1):5-9. doi: 10.1007/s11906-009-0083-9.
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. Multiple quantitative trait loci associated with hemodynamic and metabolic parameters have been mapped in the SHR. Recently, it has become possible to identify some of the specific quantitative trait gene (QTG) variants that underlie quantitative trait loci linked to complex cardiovascular and metabolic traits in SHR related strains. Recombinant inbred strains derived from SHR and Brown Norway progenitors, together with SHR congenic and transgenic strains, have proven useful for establishing the identity of several QTGs in SHR models. It is anticipated that the combined use of linkage analyses and gene expression profiles, together with the recently available genome sequences of both the SHR and Brown Norway strains and new methods for manipulating the rat genome, will soon accelerate progress in identifying QTGs for complex traits in SHR-related strains.
自发性高血压大鼠（SHR）是最广泛应用于原发性高血压及其相关代谢紊乱的动物模型。多个与血流动力学和代谢参数相关的数量性状基因座已在 SHR 中被定位。最近，已经有可能鉴定出一些特定的数量性状基因（QTG）变体，这些变体是与 SHR 相关品系中复杂心血管和代谢特征相关的数量性状基因座所连接的基础。源自 SHR 和 Brown Norway 亲本品系的重组近交系，以及 SHR 同源导入系和转基因系，已被证明对于确定 SHR 模型中几个 QTG 的身份非常有用。预计，将连锁分析和基因表达谱以及最近获得的 SHR 和 Brown Norway 品系的基因组序列以及用于操纵大鼠基因组的新方法结合使用，将很快加速鉴定 SHR 相关品系中复杂特征的 QTG 的进展。
