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高龄孕妇的产科管理

Obstetrical management of the older gravida.

作者信息

Franz Maximilian B, Husslein Peter W

机构信息

University Clinic of Obstetrics & Gynecology, Department for Feto-Maternal Medicine, Medical University Vienna, General Hospital Vienna, Vienna, Austria. maximilian.franz@ meduniwien.ac.at

出版信息

Womens Health (Lond). 2010 May;6(3):463-8. doi: 10.2217/whe.10.26.

Abstract

In developed countries, an increase in the average age of the gravida has been documented. The mean age of primiparous women in Austria rose from 25 years in 1991 to 28 years in 2008. In Germany in 2006, most gravidas were between the ages of 30 and 34 years whereas in the 1970s, most babies were born to women aged 20-24 years. Delayed childbearing and increased maternal age are associated with increased obstetrical and perinatal complications and, therefore, require adjustments in obstetrical management. Increasing maternal age is associated with pre-existing maternal risk factors such as diabetes mellitus, hypertension, myomas or obesity. In addition to lower fecundability and higher rates of chromosomal aberrations, higher rates of spontaneous early abortion are also common complications in early pregnancy among older women. In ongoing pregnancies, complications such as gestational diabetes, hypertensive disorders and low birth weight are associated with increasing maternal age. Furthermore, gravidas of advanced age are at a higher risk for stillbirth and perinatal morbidity and mortality. At delivery, increased maternal age is associated with an increased rate of malpresentation and represents an independent odds ratio for cesarean section. Owing to these facts, obstetric management in the older gravida needs to be adapted in order to manage the possible complications.

摘要

在发达国家,已有文献记载孕妇平均年龄有所增加。奥地利初产妇的平均年龄从1991年的25岁升至2008年的28岁。2006年在德国,大多数孕妇年龄在30至34岁之间,而在20世纪70年代,大多数婴儿的母亲年龄在20至24岁之间。生育延迟和孕产妇年龄增加与产科及围产期并发症增多相关,因此需要调整产科管理。孕产妇年龄增加与糖尿病、高血压、肌瘤或肥胖等既往存在的孕产妇风险因素有关。除了生育能力降低和染色体畸变率升高外,高龄女性早期妊娠中自然流产率较高也是常见并发症。在持续妊娠中,妊娠期糖尿病、高血压疾病和低出生体重等并发症与孕产妇年龄增加有关。此外,高龄孕妇死产以及围产期发病率和死亡率的风险更高。分娩时,孕产妇年龄增加与胎位异常率增加有关,并且是剖宫产的一个独立比值比。鉴于这些情况,需要调整高龄孕妇的产科管理,以应对可能出现的并发症。

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