Libbey Jane E, Kirkman Nikki J, Wilcox Karen S, White H Steve, Fujinami Robert S
Department of Pathology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA.
J Virol. 2010 Jul;84(13):6452-60. doi: 10.1128/JVI.00422-10. Epub 2010 Apr 28.
Complement, part of the innate immune system, acts to remove pathogens and unwanted host material. Complement is known to function in all tissues, including the central nervous system (CNS). In this study, we demonstrated the importance of the complement system within the CNS in the development of behavioral seizures following Theiler's murine encephalomyelitis virus (TMEV) infection. C57BL/6 mice, deficient in complement component C3, developed significantly fewer behavioral seizures following TMEV infection, whereas mice depleted of complement component C3 in the periphery through treatment with cobra venom factor had a seizure rate comparable to that of control mice. These studies indicate that C3 participates in the induction of acute seizures during viral encephalitis.
补体作为固有免疫系统的一部分，其作用是清除病原体和不需要的宿主物质。已知补体在包括中枢神经系统（CNS）在内的所有组织中发挥作用。在本研究中，我们证明了中枢神经系统内补体系统在泰勒氏鼠脑脊髓炎病毒（TMEV）感染后行为性癫痫发作发展过程中的重要性。缺乏补体成分C3的C57BL/6小鼠在TMEV感染后发生行为性癫痫发作的次数明显减少，而通过眼镜蛇毒因子处理使外周补体成分C3耗竭的小鼠，其癫痫发作率与对照小鼠相当。这些研究表明，C3参与病毒性脑炎期间急性癫痫发作的诱导。
