小胶质细胞耗竭在中枢神经系统低水平微小核糖核酸病毒感染中是致命的。
Microglial cell depletion is fatal with low level picornavirus infection of the central nervous system.
机构信息
Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT, 84112, USA.
Department of Oncological Sciences, Huntsman Cancer Institute, 2000 Circle of Hope, 2724 HCI-SOUTH, Salt Lake City, UT, 84112, USA.
出版信息
J Neurovirol. 2019 Jun;25(3):415-421. doi: 10.1007/s13365-019-00740-3. Epub 2019 Mar 11.
Abstract
Microglia are the only resident myeloid cell in the central nervous system (CNS) parenchyma, but the role of microglia in the context of neurotropic viral infection is poorly understood. Using different amounts of Theiler's murine encephalomyelitis virus (TMEV) in a preclinical model of epilepsy and PLX5622, a colony stimulating factor-1 receptor inhibitor that selectively depletes microglia in the CNS, we report that microglia-depleted, TMEV-infected mice develop seizures, manifest paralysis, and uniformly succumb to fatal encephalitis regardless of viral amount. CNS demyelination correlates with viral amount; however, viral amount does not correlate with axon damage and TMEV antigen in the CNS.
摘要
小胶质细胞是中枢神经系统（CNS）实质中唯一的固有髓样细胞，但小胶质细胞在神经嗜性病毒感染中的作用还知之甚少。我们在癫痫的临床前模型中使用不同量的 Theiler's 鼠脑脊髓炎病毒（TMEV）和 PLX5622（一种选择性耗尽中枢神经系统中小胶质细胞的集落刺激因子-1 受体抑制剂），报告称小胶质细胞耗竭、TMEV 感染的小鼠会出现癫痫发作、瘫痪，并均死于致命性脑炎，而与病毒量无关。CNS 脱髓鞘与病毒量相关；然而，病毒量与中枢神经系统中的轴突损伤和 TMEV 抗原无关。
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