补体成分在病毒感染后早期由浸润的巨噬细胞/活化的小胶质细胞表达。
Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection.
作者信息
Libbey Jane E, Cusick Matthew F, Doty Daniel J, Fujinami Robert S
机构信息
Department of Pathology, University of Utah School of Medicine , Salt Lake City, Utah.
出版信息
Viral Immunol. 2017 Jun;30(5):304-314. doi: 10.1089/vim.2016.0175. Epub 2017 Apr 12.
Abstract
The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.
摘要
个体先天免疫成分白细胞介素-6和补体成分C3，在泰勒氏鼠脑脊髓炎病毒诱导的癫痫模型中急性癫痫发作的发展过程中发挥作用。我们在感染后前3天的时间进程内，检测了大脑内以及分离出的分支状小胶质细胞和浸润性巨噬细胞/活化小胶质细胞群体中各种其他补体成分、细胞因子、趋化因子和主要组织相容性复合体抗原的mRNA表达。我们发现，在所检测的所有补体成分中，补体成分C3在大脑中的表达增加最为显著，并且其在浸润性巨噬细胞/活化小胶质细胞中的表达水平高于分支状小胶质细胞。
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