Cascade Elisa F, Kalali Amir H, Blier Pierre
Ms. Cascade is Vice President, Strategic Research and Safety, Quintiles Inc., Falls Church, Virginia.
Psychiatry (Edgmont). 2007 Nov;4(11):25-7.
We investigated the use of antidepressants in the treatment of depression. According to our data, antidepressants are most commonly used alone (85%); however, the prevalence of antidepressant monotherapy decreases as the physician's impression of patient severity increases (92% mild, 84% moderate, 73% severe). Psychiatrists are more likely to use antidepressant combinations than primary care physicians (32% vs. 8%). With respect to combination therapy, the most likely agent to be used in combination with an antidepressant in the treatment of depression was another antidepressant (6.4%); followed by anxiety agents (5.2%), antipsychotics (2.4%), and mood stabilizers and sleep aids (1.2% each). An expert commentary on the data is provided.
我们调查了抗抑郁药在抑郁症治疗中的使用情况。根据我们的数据，抗抑郁药最常单独使用（85%）；然而，随着医生对患者严重程度的判断增加，抗抑郁药单一疗法的比例会下降（轻度92%，中度84%，重度73%）。精神科医生比初级保健医生更有可能使用抗抑郁药联合疗法（32%对8%）。关于联合治疗，在抑郁症治疗中最有可能与抗抑郁药联合使用的药物是另一种抗抑郁药（6.4%）；其次是抗焦虑药（5.2%）、抗精神病药（2.4%）以及心境稳定剂和助眠剂（各1.2%）。本文还提供了对这些数据的专家评论。
