Madupu Ramana, Brinkac Lauren M, Harrow Jennifer, Wilming Laurens G, Böhme Ulrike, Lamesch Philippe, Hannick Linda I
Informatics, J. Craig Venter Institute, Rockville, MD 20850 USA, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK and The Arabidopsis Information Resource, Carnegie Institution of Washington, Stanford, CA 94305 USA.
Database (Oxford). 2010;2010:baq001. doi: 10.1093/database/baq001. Epub 2010 Feb 18.
Efforts to annotate the genomes of a wide variety of model organisms are currently carried out by sequencing centers, model organism databases and academic/institutional laboratories around the world. Different annotation methods and tools have been developed over time to meet the needs of biologists faced with the task of annotating biological data. While standardized methods are essential for consistent curation within each annotation group, methods and tools can differ between groups, especially when the groups are curating different organisms. Biocurators from several institutes met at the Third International Biocuration Conference in Berlin, Germany, April 2009 and hosted the 'Best Practices in Genome Annotation: Inference from Evidence' workshop to share their strategies, pipelines, standards and tools. This article documents the material presented in the workshop.
目前,世界各地的测序中心、模式生物数据库以及学术/机构实验室都在努力对各种模式生物的基因组进行注释。随着时间的推移,已经开发出了不同的注释方法和工具,以满足面临注释生物数据任务的生物学家的需求。虽然标准化方法对于每个注释组内的一致管理至关重要,但不同组之间的方法和工具可能会有所不同,尤其是当这些组在注释不同的生物时。来自多个机构的生物注释专家于2009年4月在德国柏林召开的第三届国际生物注释会议上会面,并主办了“基因组注释的最佳实践:基于证据的推断”研讨会,以分享他们的策略、流程、标准和工具。本文记录了研讨会上展示的材料。