Aging Center, Medicine and Rheumatology, University of California at Davis School of Medicine, 4800 2nd Avenue, Suite 2600, Sacramento, CA 95817, USA.
Curr Rheumatol Rep. 2010 Aug;12(4):259-63. doi: 10.1007/s11926-010-0106-1.
Vitamin D3, or cholecalciferol, is the naturally occurring form of vitamin D that is converted in the skin and hydroxylated in the liver and kidney to the active form found in humans. The main role for vitamin D is calcium homeostasis, and low levels of vitamin D result in lower gastrointestinal absorption of calcium. Vitamin D is also critical for mineralization of bone tissue, muscle function, and coordination. Recent studies have found prevention of bone mass loss and reduction in falls and fractures in patients supplemented with vitamin D. A high percentage of systemic lupus erythematosus patients are reported to have insufficient or deficient levels of vitamin D. This paper reviews the biology of vitamin D, its role in calcium homeostasis, and how it contributes to the maintenance of bone, muscle, and joint function in older adults and individuals with systemic lupus erythematosus.
维生素 D3，又称胆钙化醇，是维生素 D 的天然存在形式，在皮肤中转化，并在肝脏和肾脏中羟化，形成人体中存在的活性形式。维生素 D 的主要作用是维持钙平衡，维生素 D 水平低会导致胃肠道对钙的吸收减少。维生素 D 对骨组织矿化、肌肉功能和协调也至关重要。最近的研究发现，补充维生素 D 可预防骨量流失，并减少患者跌倒和骨折的发生。据报道，有很大比例的系统性红斑狼疮患者维生素 D 水平不足或缺乏。本文综述了维生素 D 的生物学特性、在钙平衡中的作用，以及它如何有助于维持老年人和系统性红斑狼疮患者的骨骼、肌肉和关节功能。
