• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

丙酮酸脱氢酶上其他位点的磷酸化会抑制丙酮酸脱氢酶磷酸磷酸酶对其的再激活作用。

Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.

作者信息

Sugden P H, Hutson N J, Kerbey A L, Randle P J

出版信息

Biochem J. 1978 Feb 1;169(2):433-5. doi: 10.1042/bj1690433.

DOI:10.1042/bj1690433
PMID:204298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1184185/
Abstract

The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.

摘要

除失活位点外的其他位点发生磷酸化，会抑制猪心丙酮酸脱氢酶磷酸酶将无活性的丙酮酸脱氢酶磷酸复合物转化为有活性的猪心丙酮酸脱氢酶复合物。

相似文献

1
Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.丙酮酸脱氢酶上其他位点的磷酸化会抑制丙酮酸脱氢酶磷酸磷酸酶对其的再激活作用。
Biochem J. 1978 Feb 1;169(2):433-5. doi: 10.1042/bj1690433.
2
Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase.源自丙酮酸脱氢酶的肽段作为丙酮酸脱氢酶激酶和磷酸酶的底物。
Biochem Biophys Res Commun. 1977 Apr 11;75(3):541-9. doi: 10.1016/0006-291x(77)91506-6.
3
Dephosphorylation of pig heart pyruvate dehydrogenase phosphate complexes by pig heart pyruvate dehydrogenase phosphate phosphatase.猪心丙酮酸脱氢酶磷酸酶对猪心丙酮酸脱氢酶磷酸复合物的去磷酸化作用。
Biochem J. 1981 Apr 1;195(1):51-9. doi: 10.1042/bj1950051.
4
Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo. Relation to proportion of inactive complex and rate of re-activation by phosphatase.大鼠心脏丙酮酸脱氢酶磷酸化复合物磷酸化位点的体内占有率。与无活性复合物比例及磷酸酶再激活速率的关系。
Biochem J. 1982 Aug 15;206(2):221-9. doi: 10.1042/bj2060221.
5
Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet.大鼠附睾脂肪垫中丙酮酸脱氢酶及丙酮酸脱氢酶磷酸磷酸酶活性的调节。饥饿、四氧嘧啶糖尿病及高脂饮食的影响。
Biochem J. 1976 Jan 15;154(1):225-36. doi: 10.1042/bj1540225.
6
Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat.大鼠体内的四氧嘧啶糖尿病或饥饿会抑制心脏线粒体中通过磷酸反应将无活性（磷酸化）丙酮酸脱氢酶复合体转化为活性复合体的过程。
Biochem J. 1978 Aug 1;173(2):669-680. doi: 10.1042/bj1730669.
7
Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.乙酰辅酶A/辅酶A和NADH/NAD比值对丙酮酸脱氢酶激酶和磷酸酶的调节作用。
Biochem Biophys Res Commun. 1975 Jul 22;65(2):575-82. doi: 10.1016/s0006-291x(75)80185-9.
8
Activation of pyruvate dehydrogenase in adipose tissue by insulin. Evidence for an effect of insulin on pyruvate dehydrogenase phosphate phosphatase.胰岛素对脂肪组织中丙酮酸脱氢酶的激活作用。胰岛素对丙酮酸脱氢酶磷酸磷酸酶作用的证据。
Biochem J. 1975 May;148(2):229-35. doi: 10.1042/bj1480229.
9
Role of multi-site phosphorylation in regulation of pig heart pyruvate dehydrogenase phosphatase.多位点磷酸化在猪心脏丙酮酸脱氢酶磷酸酶调节中的作用。
FEBS Lett. 1979 Dec 15;108(2):485-8. doi: 10.1016/0014-5793(79)80594-3.
10
The effect of lead nitrate on purified pig heart pyruvate dehydrogenase [proceedings].硝酸铅对纯化猪心丙酮酸脱氢酶的影响[会议论文集]
Biochem Soc Trans. 1979 Oct;7(5):1124-6. doi: 10.1042/bst0071124.

引用本文的文献

1
Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.组织特异性激酶的表达和活性调节丙酮酸脱氢酶复合物中的通量。
J Biol Chem. 2019 Jan 18;294(3):838-851. doi: 10.1074/jbc.RA118.006433. Epub 2018 Nov 27.
2
Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.采用 iTRAQ 标记联合 LTQ-Orbitrap 高能量碰撞解离技术进行定量线粒体磷酸化蛋白质组学分析。
J Proteome Res. 2009 Oct;8(10):4665-75. doi: 10.1021/pr900387b.
3
Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.磷酸化导致人丙酮酸脱氢酶复合体失活的结构基础：无序磷酸化环的作用
Structure. 2008 Dec 10;16(12):1849-59. doi: 10.1016/j.str.2008.10.010.
4
Metabolic aspects of low carbohydrate diets and exercise.低碳水化合物饮食与运动的代谢方面
Nutr Metab (Lond). 2004 Sep 30;1(1):7. doi: 10.1186/1743-7075-1-7.
5
Incorporation of [32P]phosphate into the pyruvate dehydrogenase complex in rat heart mitochondria.[32P]磷酸盐掺入大鼠心脏线粒体丙酮酸脱氢酶复合物的研究。
Biochem J. 1980 May 15;188(2):409-21. doi: 10.1042/bj1880409.
6
Occupancy of sites of phosphorylation in inactive rat heart pyruvate dehydrogenase phosphate in vivo.体内失活大鼠心脏丙酮酸脱氢酶磷酸化位点的占据情况。
Biochem J. 1981 Mar 1;193(3):935-46. doi: 10.1042/bj1930935.
7
Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.脂肪酸氧化抑制剂2-十四烷基缩水甘油酸对饥饿和四氧嘧啶糖尿病大鼠丙酮酸脱氢酶复合体活性的影响。
Biochem J. 1982 Oct 15;208(1):53-60. doi: 10.1042/bj2080053.
8
Role of individual phosphorylation sites in inactivation of pyruvate dehydrogenase complex in rat heart mitochondria.单个磷酸化位点在大鼠心脏线粒体丙酮酸脱氢酶复合体失活中的作用
Biochem J. 1982 Apr 1;203(1):99-108. doi: 10.1042/bj2030099.
9
Studies on the incorporation of [32P]phosphate into pyruvate dehydrogenase in intact rat fat-cells. Effects of insulin.关于[32P]磷酸盐掺入完整大鼠脂肪细胞中丙酮酸脱氢酶的研究。胰岛素的作用。
Biochem J. 1980 Nov 15;192(2):469-81. doi: 10.1042/bj1920469.
10
Proportion of active dephosphorylated pyruvate dehydrogenase complex in heart and isolated heart mitochondria is decreased in obese hyperinsulinaemic mice.肥胖高胰岛素血症小鼠心脏和分离的心脏线粒体中活性去磷酸化丙酮酸脱氢酶复合物的比例降低。
Biochem J. 1984 Jan 1;217(1):117-21. doi: 10.1042/bj2170117.

本文引用的文献

1
Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies.大鼠心肌中丙酮酸脱氢酶在脂肪酸或酮体灌注时的相互转化。
FEBS Lett. 1971 Jul 1;15(4):295-298. doi: 10.1016/0014-5793(71)80641-5.
2
Regulation of heart muscle pyruvate dehydrogenase kinase.心肌丙酮酸脱氢酶激酶的调节
Biochem J. 1974 Dec;143(3):625-41. doi: 10.1042/bj1430625.
3
Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.钙和镁离子作为脂肪组织丙酮酸脱氢酶磷酸磷酸酶的效应物。
Biochem J. 1974 May;140(2):225-37. doi: 10.1042/bj1400225.
4
Assay of cyclic AMP-dependent protein kinases.环磷酸腺苷依赖性蛋白激酶的测定
Methods Enzymol. 1974;38:287-90. doi: 10.1016/0076-6879(74)38044-5.
5
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.钙离子对丙酮酸脱氢酶磷酸磷酸酶的刺激作用。
Biochem J. 1972 Jun;128(1):161-3. doi: 10.1042/bj1280161.
6
Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.大鼠心脏和肾脏中丙酮酸脱氢酶的活性和非活性形式：糖尿病、禁食和再喂养对丙酮酸脱氢酶相互转化的影响。
Arch Biochem Biophys. 1971 Apr;143(2):593-601. doi: 10.1016/0003-9861(71)90244-x.
7
Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.α-酮酸脱氢酶复合体。X. 牛肉肾线粒体丙酮酸脱氢酶复合体活性的磷酸化和去磷酸化调节
Proc Natl Acad Sci U S A. 1969 Jan;62(1):234-41. doi: 10.1073/pnas.62.1.234.
8
Emergency medicine.急诊医学
J Med Assoc State Ala. 1976 Apr;45(9):38-40.
9
Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.糖尿病与大鼠心脏线粒体中丙酮酸脱氢酶的调控：通过三磷酸腺苷/二磷酸腺苷、还原型/氧化型烟酰胺腺嘌呤二核苷酸以及乙酰辅酶A/辅酶A的浓度比进行调控
Biochem J. 1977 Jun 15;164(3):509-19. doi: 10.1042/bj1640509.
10
Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase.源自丙酮酸脱氢酶的肽段作为丙酮酸脱氢酶激酶和磷酸酶的底物。
Biochem Biophys Res Commun. 1977 Apr 11;75(3):541-9. doi: 10.1016/0006-291x(77)91506-6.