大鼠附睾脂肪垫中丙酮酸脱氢酶及丙酮酸脱氢酶磷酸磷酸酶活性的调节。饥饿、四氧嘧啶糖尿病及高脂饮食的影响。
Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet.
作者信息
Stansbie D, Denton R M, Bridges B J, Pask H T, Randle P J
出版信息
Biochem J. 1976 Jan 15;154(1):225-36. doi: 10.1042/bj1540225.
Abstract
- Pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads was measured by using pig heart pyruvate dehydrogenase [32P]phosphate. About 80% was found to be extramitochondrial and therefore probably not directly concerned with the regulation of pyruvate dehydrogenase activity. The extramitochondrial activity was sensitive to activation by Ca2+, but perhaps less sensitive than the mitochondrial activity.
摘要
- 通过使用猪心丙酮酸脱氢酶[32P]磷酸酯来测定大鼠附睾脂肪垫中的丙酮酸脱氢酶磷酸磷酸酶活性。发现约80%的活性存在于线粒体外，因此可能与丙酮酸脱氢酶活性的调节没有直接关系。线粒体外的活性对Ca2+激活敏感，但可能不如线粒体活性敏感。
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