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大鼠附睾脂肪垫中丙酮酸脱氢酶及丙酮酸脱氢酶磷酸磷酸酶活性的调节。饥饿、四氧嘧啶糖尿病及高脂饮食的影响。

Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet.

作者信息

Stansbie D, Denton R M, Bridges B J, Pask H T, Randle P J

出版信息

Biochem J. 1976 Jan 15;154(1):225-36. doi: 10.1042/bj1540225.

DOI:10.1042/bj1540225
PMID:6018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172695/
Abstract
  1. Pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads was measured by using pig heart pyruvate dehydrogenase [32P]phosphate. About 80% was found to be extramitochondrial and therefore probably not directly concerned with the regulation of pyruvate dehydrogenase activity. The extramitochondrial activity was sensitive to activation by Ca2+, but perhaps less sensitive than the mitochondrial activity.
摘要
  1. 通过使用猪心丙酮酸脱氢酶[32P]磷酸酯来测定大鼠附睾脂肪垫中的丙酮酸脱氢酶磷酸磷酸酶活性。发现约80%的活性存在于线粒体外，因此可能与丙酮酸脱氢酶活性的调节没有直接关系。线粒体外的活性对Ca2+激活敏感，但可能不如线粒体活性敏感。

相似文献

1
Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet.大鼠附睾脂肪垫中丙酮酸脱氢酶及丙酮酸脱氢酶磷酸磷酸酶活性的调节。饥饿、四氧嘧啶糖尿病及高脂饮食的影响。
Biochem J. 1976 Jan 15;154(1):225-36. doi: 10.1042/bj1540225.
2
Activation of pyruvate dehydrogenase in adipose tissue by insulin. Evidence for an effect of insulin on pyruvate dehydrogenase phosphate phosphatase.胰岛素对脂肪组织中丙酮酸脱氢酶的激活作用。胰岛素对丙酮酸脱氢酶磷酸磷酸酶作用的证据。
Biochem J. 1975 May;148(2):229-35. doi: 10.1042/bj1480229.
3
Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin.钙离子在大鼠附睾脂肪组织线粒体内代谢调节中的作用。关于钙离子在胰岛素激活丙酮酸脱氢酶中不起作用的证据。
Biochem J. 1984 Feb 15;218(1):249-60. doi: 10.1042/bj2180249.
4
Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat.大鼠体内的四氧嘧啶糖尿病或饥饿会抑制心脏线粒体中通过磷酸反应将无活性（磷酸化）丙酮酸脱氢酶复合体转化为活性复合体的过程。
Biochem J. 1978 Aug 1;173(2):669-680. doi: 10.1042/bj1730669.
5
Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin.丙酮酸脱氢酶磷酸磷酸酶对镁离子的敏感性。精胺和胰岛素的类似作用。
Biochem J. 1986 Aug 15;238(1):83-91. doi: 10.1042/bj2380083.
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Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.钙和镁离子作为脂肪组织丙酮酸脱氢酶磷酸磷酸酶的效应物。
Biochem J. 1974 May;140(2):225-37. doi: 10.1042/bj1400225.
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Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes.大鼠骨骼肌线粒体中丙酮酸脱氢酶的可逆磷酸化。饥饿和糖尿病的影响。
Biochem J. 1984 Apr 15;219(2):635-46. doi: 10.1042/bj2190635.
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Persistent effects of starvation on pyruvate dehydrogenase kinase and phosphatase of lactating rat mammary gland [proceedings].饥饿对泌乳大鼠乳腺丙酮酸脱氢酶激酶和磷酸酶的持续影响[会议论文集]
Biochem Soc Trans. 1978;6(1):154-7. doi: 10.1042/bst0060154.
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Effects of protein phosphatase inhibitors on the regulation of insulin-sensitive enzymes within rat epididymal fat-pads and cells.蛋白磷酸酶抑制剂对大鼠附睾脂肪垫及细胞内胰岛素敏感性酶调节的影响。
Biochem J. 1991 Jun 15;276 ( Pt 3)(Pt 3):649-54. doi: 10.1042/bj2760649.
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The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin.泌乳大鼠乳腺丙酮酸脱氢酶的调节模式。饥饿和胰岛素的影响。
Biochem J. 1978 Aug 15;174(2):553-61. doi: 10.1042/bj1740553.

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Dietary effect on lipogenesis in adipose tissue.饮食对脂肪组织脂肪生成的影响。
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A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
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Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies.大鼠心肌中丙酮酸脱氢酶在脂肪酸或酮体灌注时的相互转化。
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Measurement of flow of carbon atoms from glucose and glycogen glucose to glyceride glycerol and glycerol in rat heart and epididymal adipose tissue. Effects of insulin, adrenaline and alloxan-diabetes.大鼠心脏和附睾脂肪组织中碳原子从葡萄糖、糖原葡萄糖流向甘油三酯甘油和甘油的流量测定。胰岛素、肾上腺素和四氧嘧啶糖尿病的影响。
Biochem J. 1967 Aug;104(2):423-34. doi: 10.1042/bj1040423.
7
Studies on the metabolic effects induced in the rat by a high fat diet. I. Carbohydrate metabolism in vivo.高脂饮食对大鼠代谢影响的研究。I. 体内碳水化合物代谢
Horm Metab Res. 1970 Nov;2(6):323-9. doi: 10.1055/s-0028-1095057.
8
Secretion of and sensitivity to insulin in obese rats fed a high-fat diet.喂食高脂饮食的肥胖大鼠的胰岛素分泌及胰岛素敏感性
Horm Metab Res. 1969 Jan;1(1):9-13. doi: 10.1055/s-0028-1095167.
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Interactions of metabolism and the physiological role of insulin.新陈代谢的相互作用及胰岛素的生理作用。
Recent Prog Horm Res. 1966;22:1-48. doi: 10.1016/b978-1-4831-9825-5.50004-x.
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Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones.胰岛素及其他激素对脂肪组织丙酮酸脱氢酶的调节作用。
Biochem J. 1971 Nov;125(1):115-27. doi: 10.1042/bj1250115.