Department of Radiology, Gifu University Hospital, Gifu, Japan.
J Magn Reson Imaging. 2010 May;31(5):1151-6. doi: 10.1002/jmri.22157.
To compare (11)C-choline positron emission tomography (C-PET), (18)F-fluorodeoxyglucose PET (FDG-PET), and MR imaging in the preoperative detection of prostate cancer.
C-PET, FDG-PET, and MR images were obtained in 43 consecutive patients with suspected prostate cancer, and prostate cancers were histopathologically confirmed in 26 patients. Unenhanced T1-weighted, T2-weighted, and gadolinium-enhanced MR images were obtained. C-PET and FDG-PET were conducted 1.5 and 60 minutes after injection of 5.5 and 5.0 MBq/kg tracers, respectively. A nuclear and a genitourinary radiologist retrospectively reviewed PET and MR images at random, respectively, and assigned a confidence level for the presence of prostate cancer using a four-point scale. Diagnostic performance was tested using the McNemar test and receiver operating characteristic curve analysis.
The sensitivity was greater (P < 0.05) with MR (88%) and C-PET (73%) images than with FDG-PET images (31%). The accuracy was greater (P < 0.05) with MR images (88%) than with C-PET (67%) and FDG-PET (53%) images. The area-under-curve value with MR (0.90) was greater than those with C-PET (0.53) and FDG-PET (0.54) images (P < 0.01).
MR imaging should be primarily performed in the preoperative detection of prostate cancer. C-PET and FDG-PET did not improve the detection.
比较（11）C-胆碱正电子发射断层扫描（C-PET）、（18）F-氟代脱氧葡萄糖 PET（FDG-PET）和磁共振成像在前列腺癌术前检测中的作用。
对 43 例疑似前列腺癌患者进行了 C-PET、FDG-PET 和 MR 成像检查，其中 26 例患者经组织病理学证实患有前列腺癌。获得了未增强 T1 加权、T2 加权和钆增强磁共振图像。在注射 5.5 和 5.0 MBq/kg 示踪剂后 1.5 和 60 分钟分别进行 C-PET 和 FDG-PET。一名核医学和泌尿生殖系统放射科医生分别对 PET 和 MR 图像进行了回顾性随机审查，并使用四点量表对前列腺癌的存在程度进行了信心评估。使用 McNemar 检验和受试者工作特征曲线分析来测试诊断性能。
MR（88%）和 C-PET（73%）图像的敏感性（P <0.05）高于 FDG-PET 图像（31%）。MR 图像的准确性（P <0.05）高于 C-PET（67%）和 FDG-PET（53%）图像。MR（0.90）的曲线下面积值大于 C-PET（0.53）和 FDG-PET（0.54）图像（P <0.01）。
在术前检测前列腺癌时，应首选进行 MR 成像。C-PET 和 FDG-PET 并不能提高检测效果。
Zotero 插件