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前列腺癌的分子成像

Molecular imaging of prostate cancer.

作者信息

Boustani Anne Marie, Pucar Darko, Saperstein Lawrence

机构信息

1 Department of Radiology and Biomedical Imaging, Yale University School of Medicine , New Haven, CT , USA.

出版信息

Br J Radiol. 2018 Apr;91(1084):20170736. doi: 10.1259/bjr.20170736. Epub 2018 Feb 1.

Abstract

Prostate cancer is a common malignancy with various treatments from surveillance, surgery, radiation and chemotherapy. The institution of appropriate, effective treatment relies in part on accurate imaging. Molecular imaging techniques offer an opportunity for increased timely detection of prostate cancer, its recurrence, as well as metastatic disease. Advancements within the field of molecular imaging have been complex with some agents targeting receptors and others acting as metabolic intermediaries. In this article, we provide an overview of the most clinically relevant radiotracers to date based on a combination of the five states model and the National Comprehensive Cancer Network Guidelines.

摘要

前列腺癌是一种常见的恶性肿瘤,有多种治疗方法,包括监测、手术、放疗和化疗。恰当、有效的治疗方案的确立部分依赖于精确的成像检查。分子成像技术为更早地检测前列腺癌、其复发情况以及转移性疾病提供了契机。分子成像领域的进展较为复杂,有些试剂靶向受体,另一些则作为代谢中间体发挥作用。在本文中,我们结合五态模型和美国国立综合癌症网络指南,概述了迄今为止临床上最相关的放射性示踪剂。

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