Karimi-Yazdi Alireza, Motiee-Langroudi Maziar, Saedi Babak, Ensani Freshteh, Amali Amin, Memari Fereidon, Dabiri Maryam, Seifmanesh Hamidreza
Department of Otolaryngology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Department of Otolaryngology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran ; Otolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Bagherkhan Street, Chamran Highway, 141973141 Tehran, Iran.
Indian J Otolaryngol Head Neck Surg. 2014 Jan;66(Suppl 1):277-80. doi: 10.1007/s12070-012-0484-y. Epub 2012 Feb 11.
The objective of this paper was that fine-needle aspiration (FNA) has become a well-liked modality in the diagnosis, staging, and follow-up of head and neck masses. Limited studies exist regarding the value of FNA in the diagnosis of head and neck masses. We aimed to evaluate the diagnostic value of head and neck lymphomas. This cross-sectional study method was performed in Imam Hospital and Cancer Institute affiliated to Tehran University of Medical Sciences. In a 5 years period between January 2006 and June 2010, we enrolled all patients with cervical mass (es) who had undergone FNA as the primary diagnostic modality and then underwent biopsy (excisional or open). Results of FNA were compared with histopathological study as a gold standard method. Finally, 47 patients were recruited. It was found that FNA had a sensitivity of 88% (CI 95% = 79-97), a specificity of 81.2% (CI 95% = 70-92), a positive predictive value of 84.6% (CI 95% = 75-95), a negative predictive value of 85.7% (CI 95% = 77-95) and an accuracy of 85.1% (CI 95% = 75-95) in the diagnosis of head and neck lymphoma. We conclude that FNA has a considerable value in differentiation of head and neck lymphoma from non-lymphoma etiologies and is recommended as a screening test for the diagnosis of head and neck lymphoma.
本文的目的是，细针穿刺抽吸活检（FNA）已成为头颈部肿块诊断、分期及随访中一种广受欢迎的方式。关于FNA在头颈部肿块诊断中的价值，现有研究有限。我们旨在评估头颈部淋巴瘤的诊断价值。本横断面研究方法在德黑兰医科大学附属伊玛目医院和癌症研究所开展。在2006年1月至2010年6月的5年期间，我们纳入了所有以FNA作为主要诊断方式且随后接受活检（切除活检或切开活检）的颈部肿块患者。将FNA的结果与作为金标准方法的组织病理学研究结果进行比较。最终，招募了47例患者。结果发现，FNA在头颈部淋巴瘤诊断中的灵敏度为88%（95%置信区间=79 - 97），特异度为81.2%（95%置信区间=70 - 92），阳性预测值为84.6%（95%置信区间=75 - 95），阴性预测值为85.7%（95%置信区间=77 - 95），准确率为85.1%（95%置信区间=75 - 95）。我们得出结论，FNA在鉴别头颈部淋巴瘤与非淋巴瘤病因方面具有相当大的价值，推荐将其作为头颈部淋巴瘤诊断的筛查试验。
