结核性脑膜炎直接观察短程治疗初步报告
Preliminary report of directly observed treatment, short course in tuberculous meningitis.
作者信息
Iype Thomas, Chacko Sinchu, Raghavan Sivadasan, Mathew Robert, Mohan Madhusudanan
机构信息
Department of Neurology, Medical College, Thiruvananthapuram, India.
出版信息
Ann Indian Acad Neurol. 2010 Jan;13(1):57-60. doi: 10.4103/0972-2327.61279.
BACKGROUND
Diagnosis of tuberculous meningitis (TBM) is a challenge because of the manifold clinical presentation, and diagnosis is often delayed.
OBJECTIVES
We wanted to share our experience of directly observed treatment short course (DOTS) in TBM. We did a retrospective analysis to look at the presentation, management and outcome of TBM patients from November 2006 to April 2008.
MATERIALS AND METHODS
TBM was diagnosed based on clinical criteria. We excluded patients with HIV.
RESULTS
We had 11 patients on DOTS regime. One died following hepatitis and another patient died of unrelated gastroenteritis. The only patient on daily regime died. Our patients generally presented late, at a median duration 20 days from onset of symptoms, and 50% had stage 3 disease at presentation. The median delay in diagnosis was 4.5 days.
DISCUSSION
We found DOTS to be effective in TBM but not without side effects.
背景
结核性脑膜炎（TBM）的诊断颇具挑战，因其临床表现多样，诊断往往延迟。
目的
我们希望分享在TBM患者中实施直接观察下短程治疗（DOTS）的经验。我们进行了一项回顾性分析，以观察2006年11月至2008年4月期间TBM患者的临床表现、治疗及转归情况。
材料与方法
根据临床标准诊断TBM。我们排除了感染HIV的患者。
结果
我们有11例患者接受DOTS治疗方案。1例患者死于肝炎，另1例死于无关的肠胃炎。每日治疗方案的唯一1例患者死亡。我们的患者通常就诊较晚，从症状出现到就诊的中位时长为20天，50%的患者就诊时处于3期疾病。诊断的中位延迟时间为4.5天。
讨论
我们发现DOTS对TBM有效，但并非没有副作用。
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