Prasat Neurological Institute, 312 Rajvitee Rajtavee, Bangkok, 10400, Thailand.
Curr Neurol Neurosci Rep. 2010 Jul;10(4):299-307. doi: 10.1007/s11910-010-0114-6.
About one third of patients with focal epilepsy experience seizures despite adequate medical treatment. In this population, successful epilepsy surgery improves life expectancy and health-related quality of life, while reducing health care costs as a result of reduced hospital admissions, emergency department visits, and use of antiepileptic drugs. The effectiveness of epilepsy surgery and low incidence of surgical complications have been established by numerous studies over several decades. The International League Against Epilepsy recently issued a definition of drug-resistant epilepsy for early identification of patients who are unlikely to be treated successfully with medical therapy alone. Potential surgical candidates are identified through a detailed seizure and medical history, physical examination, and the use of video electroencephalography and neuroimaging. A presurgical evaluation should be considered as soon as drug resistance becomes evident.
尽管进行了充分的医学治疗，仍有约三分之一的局灶性癫痫患者会出现癫痫发作。在这部分人群中，成功的癫痫手术可以提高预期寿命和健康相关的生活质量，同时降低因住院、急诊就诊和抗癫痫药物使用减少而带来的医疗保健费用。数十年来，多项研究证实了癫痫手术的有效性和较低的手术并发症发生率。国际抗癫痫联盟最近发布了耐药性癫痫的定义，以便早期识别那些仅凭药物治疗不太可能成功的患者。通过详细的癫痫发作和病史、体格检查以及视频脑电图和神经影像学检查来确定潜在的手术候选者。一旦出现耐药性，就应考虑进行术前评估。
