Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation (JST), Suita, Osaka, Japan.
Curr Opin Genet Dev. 2010 Aug;20(4):433-7. doi: 10.1016/j.gde.2010.04.002. Epub 2010 May 1.
The breaking of left-right symmetry in the mouse involves unidirectional fluid flow. Rotational movement of the node cilia generates leftward flow because the cilia are posteriorly tilted. However, it is unknown how anterior-posterior (A-P) information is translated into the posterior tilt of the node cilia. The tilt is determined by the position of the basal body of node cilia. Some of the planar cell polarity (PCP) core proteins such as Dvl are asymmetrically distributed in the node cells, and positioning of the basal body is impaired in mutant mice lacking Dvl genes. Therefore, posterior positioning of the basal body is determined by planar polarization involving noncanonical Wnt signaling. However, the identity of initial A-P information remains unknown.
小鼠左右对称性的破坏涉及单向流体流动。节点纤毛的旋转运动产生向左的流动，因为纤毛向后倾斜。然而，目前尚不清楚如何将前后（A-P）信息转化为节点纤毛的向后倾斜。倾斜由节点纤毛的基体位置决定。一些平面细胞极性（PCP）核心蛋白，如 Dvl，在节点细胞中呈不对称分布，并且在缺乏 Dvl 基因的突变小鼠中，基体的定位受到损害。因此，基体的后定位由涉及非经典 Wnt 信号的平面极化决定。然而，初始 A-P 信息的身份仍然未知。
