Swenson Karen K, Nissen Mary Jo, Henly Susan J
Oncology Research Department, Park Nicollet Institute, Minneapolis, MN, USA.
Oncol Nurs Forum. 2010 May;37(3):321-30. doi: 10.1188/10.ONF.321-330.
PURPOSE/OBJECTIVES: To describe and predict adherence to a physical activity protocol for patients with breast cancer receiving chemotherapy.
Longitudinal, observational study.
Cancer center in the upper Midwestern region of the United States.
36 patients with breast cancer aged 40-55 years who were receiving adjuvant treatment.
A longitudinal study was conducted within a randomized clinical trial comparing the effects of physical activity versus bisphosphonates on bone mineral density. Participants randomized to physical activity were advised to walk 10,000 steps per day and received initial physical therapy consultation and ongoing motivational interviewing. Multilevel modeling was used to identify variables that predict adherence.
Adherence to the 10,000-step protocol was estimated with total steps and mean steps per day.
Thirty-six women were enrolled in the physical activity group; 29 provided step data. The mean total steps per participant for the first six weeks was 280,571 (SD = 111,992), which is 67% of the prescribed steps. Excluding days when no steps were recorded, the mean steps per day for the initial six-week period was 7,363 (SD = 2,421), a 74% adherence rate. A significant linear increase occurred in steps per day after chemotherapy in a treatment cycle (p < 0.0001). Baseline inactivity predicted adherence.
Adherence to the walking program was compromised during chemotherapy but improved after chemotherapy completion.
Knowing that chemotherapy predicts adherence to a walking protocol is useful for selecting the type, timing, and intensity of physical activity interventions.
目的/目标：描述并预测接受化疗的乳腺癌患者对体力活动方案的依从性。
纵向观察性研究。
美国中西部上游地区的癌症中心。
36名年龄在40 - 55岁之间接受辅助治疗的乳腺癌患者。
在一项比较体力活动与双膦酸盐对骨密度影响的随机临床试验中进行纵向研究。被随机分配到体力活动组的参与者被建议每天步行10,000步，并接受初始物理治疗咨询和持续的动机访谈。采用多水平模型来确定预测依从性的变量。
通过总步数和每日平均步数来估计对10,000步方案的依从性。
36名女性被纳入体力活动组；29名提供了步数数据。每位参与者在前六周的平均总步数为280,571步（标准差 = 111,992），占规定步数的67%。排除未记录步数的日子，最初六周期间的每日平均步数为7,363步（标准差 = 2,421），依从率为74%。在一个治疗周期的化疗后，每日步数出现显著线性增加（p < 0.0001）。基线时不活动预测了依从性。
在化疗期间对步行计划的依从性受到影响，但在化疗完成后有所改善。
了解化疗可预测对步行方案的依从性，有助于选择体力活动干预的类型、时机和强度。
