Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
J Epidemiol Community Health. 2010 Oct;64(10):855-9. doi: 10.1136/jech.2008.078345. Epub 2010 May 3.
The relationship between birth weight and plasma lipoproteins is inconsistent.
To assess the association between birth weight and (1) body mass index (BMI) at birth and (2) lipoproteins in young adults, and also to explore the possible effect of current obesity as a possible effect modifier.
Two prospective studies based on representative samples of subjects born in the 1970s were carried out in Ribeirão Preto, Brazil (n=2063) and Limache, Chile (n=999). The surveys were carried out between 2001 and 2004.
Mean birth weights were 3267 g and 3177 g and mean adult BMIs were 24.3 kg/m2 and 25.8 kg/m2 in the Brazilian and Chilean samples, respectively. Total adult cholesterol was 4.57 mmol/l in Chileans, 0.26 mmol/l higher than in Brazilians (p<0.001). The main finding was an interaction between adult obesity (BMI 30 or over) and birth weight and also BMI at birth and low-density lipoprotein (LDL) and total cholesterol. A birth-weight increment of 1 kg was associated with a decrease in total cholesterol (-0.374 mmol/l, 95% CI -0.567 to -0.181) and LDL (-0.304 mmol/l (-0.479 to -0.129) in obese participants only. These associations persisted after allowing for gestational age in a smaller sample. This finding was consistent in separate analyses in the Brazilian and Chilean samples. No associations were found in relation to high-density lipoprotein and triglyceride concentrations.
The results suggest that those who were of low birth weight and are obese are more likely to have high cholesterol and LDL concentrations. Thus preventing obesity may be especially rewarding in subjects with a low birth weight.
出生体重与血浆脂蛋白之间的关系并不一致。
评估出生体重与（1）出生时的体重指数（BMI）和（2）成年后脂蛋白之间的关系，并探讨当前肥胖作为可能的效应修饰剂的可能影响。
在巴西里贝朗普雷托（n=2063）和智利利马切（n=999）进行了两项基于 20 世纪 70 年代出生的代表性样本的前瞻性研究。调查于 2001 年至 2004 年进行。
巴西和智利样本的平均出生体重分别为 3267g 和 3177g，平均成人 BMI 分别为 24.3kg/m2 和 25.8kg/m2。智利人的总胆固醇成人胆固醇为 4.57mmol/l，比巴西人高 0.26mmol/l（p<0.001）。主要发现是成年肥胖（BMI 30 或以上）与出生体重以及出生时 BMI 与低密度脂蛋白（LDL）和总胆固醇之间存在交互作用。出生体重每增加 1 公斤，与肥胖参与者总胆固醇（-0.374mmol/l，95%CI-0.567 至-0.181）和 LDL（-0.304mmol/l，-0.479 至-0.129）的降低有关。在一个较小的样本中允许胎龄后，这些关联仍然存在。这一发现与巴西和智利样本的单独分析一致。高密度脂蛋白和甘油三酯浓度与这些关联无关。
结果表明，那些出生体重较低且肥胖的人更有可能胆固醇和 LDL 浓度较高。因此，预防肥胖对于出生体重较低的人来说可能特别有益。
