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Am J Epidemiol. 1981 Feb;113(2):144-56. doi: 10.1093/oxfordjournals.aje.a113079.
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Int J Epidemiol. 1982 Jun;11(2):120-6. doi: 10.1093/ije/11.2.120.
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The inheritance of serum cholesterol: adjustment of observed cholesterol levels for age, sex and body weight using inverse-polynomial regression.血清胆固醇的遗传:使用逆多项式回归对观察到的胆固醇水平进行年龄、性别和体重调整。
Int J Epidemiol. 1982 Mar;11(1):76-81. doi: 10.1093/ije/11.1.76.
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加拿大成年人肥胖症及其与心血管疾病风险因素的关系。加拿大心脏健康调查研究小组。

Obesity and its relation to cardiovascular disease risk factors in Canadian adults. Canadian Heart Health Surveys Research Group.

作者信息

Reeder B A, Angel A, Ledoux M, Rabkin S W, Young T K, Sweet L E

机构信息

Saskatchewan Heart and Stroke Foundation Epidemiology Unit, University of Saskatchewan, Saskatoon.

出版信息

CMAJ. 1992 Jun 1;146(11):2009-19.

PMID:1596850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1490327/
Abstract

OBJECTIVE

To describe the distribution of weight and abdominal obesity among Canadian adults and to determine the association of obesity with other risk factors for cardiovascular disease.

DESIGN

Population-based cross-sectional surveys. Survey nurses administered a standard questionnaire and recorded two blood pressure measurements during a home visit. At a subsequent visit to a survey clinic two further blood pressure readings were made, anthropometric measurements recorded and a blood specimen taken for plasma lipid determination.

SETTING

Nine Canadian provinces, from 1986 to 1990.

PARTICIPANTS

A probability sample of 26,293 men and women aged 18 to 74 years was selected from the health insurance registration files of each province. Anthropometry was performed on 17,858 subjects.

OUTCOME MEASURES

Body mass index (BMI), ratio of waist to hip circumference (WHR), mean plasma lipid levels, prevalence of high blood pressure (diastolic greater than or equal to 90 mm Hg or patient on treatment) and self-reported diabetes mellitus.

MAIN RESULTS

The prevalence of obesity (BMI greater than or equal to 27) increased with age and was greater in men (35%) than in women (27%). Abdominal obesity was likewise higher in men and increased with both age and BMI. The prevalence of high blood pressure was greater in those with higher BMI, especially in those with a high WHR. Although total plasma cholesterol levels increased only modestly with BMI, levels of low density lipoprotein (LDL) cholesterol and triglycerides and the ratio of total cholesterol to high density lipoprotein (HDL) cholesterol increased steadily, while HDL-cholesterol decreased consistently with increasing BMI. High total cholesterol levels (greater than or equal to 5.2 mmol/L) were more prevalent among people with high BMI, especially those with a high WHR. The prevalence of diabetes increased with BMI among those 35 years or older, especially those with abdominal obesity. About half of men and two-thirds of women who were obese were trying to lose weight.

CONCLUSION

Obesity remains common among Canadian adults. There is a need for broad-based programs that facilitate healthy eating and activity patterns for all age groups. Health professionals should incorporate measurement of BMI and WHR into their routine examinations of patients to enhance their evaluation of health risk.

摘要

目的

描述加拿大成年人的体重分布及腹部肥胖情况,并确定肥胖与心血管疾病其他危险因素之间的关联。

设计

基于人群的横断面调查。调查护士在家庭访视期间发放标准问卷并记录两次血压测量值。在随后前往调查诊所的访视中,再次测量两次血压,记录人体测量数据,并采集血样用于血浆脂质测定。

地点

1986年至1990年期间加拿大的九个省份。

参与者

从每个省份的健康保险登记档案中选取了26293名年龄在18至74岁之间的男性和女性作为概率样本。对17858名受试者进行了人体测量。

观察指标

体重指数(BMI)、腰臀比(WHR)、平均血浆脂质水平、高血压患病率(舒张压大于或等于90毫米汞柱或正在接受治疗的患者)以及自我报告的糖尿病。

主要结果

肥胖(BMI大于或等于27)的患病率随年龄增长而增加,男性(35%)高于女性(27%)。男性的腹部肥胖同样较高,且随年龄和BMI增加而上升。BMI较高者,尤其是WHR较高者,高血压患病率更高。尽管总血浆胆固醇水平仅随BMI适度增加,但低密度脂蛋白(LDL)胆固醇和甘油三酯水平以及总胆固醇与高密度脂蛋白(HDL)胆固醇的比值稳步上升,而HDL胆固醇则随BMI增加持续下降。高总胆固醇水平(大于或等于5.2毫摩尔/升)在高BMI人群中更为普遍,尤其是WHR较高者。35岁及以上人群中,糖尿病患病率随BMI增加而上升,尤其是腹部肥胖者。约一半肥胖男性和三分之二肥胖女性正在尝试减肥。

结论

肥胖在加拿大成年人中仍然很常见。需要开展基础广泛的项目,以促进所有年龄组的健康饮食和活动模式。健康专业人员应将BMI和WHR的测量纳入对患者的常规检查中,以加强对健康风险的评估。