New York State Psychiatric Institute, 1051 Riverside Drive #123, New York, NY 10032, USA.
Am J Psychiatry. 2010 Aug;167(8):969-76. doi: 10.1176/appi.ajp.2009.09081161. Epub 2010 May 3.
The course of alcohol disorders in women is often described as "telescoped" compared to that in men, with a later age at initiation of alcohol use but shorter times from use to dependence and treatment. This study examined evidence for such a telescoping effect in the general population and tested birth cohort effects for gender differences.
Data from two U.S. national surveys conducted 10 years apart (1991-1992 and 2001-2002) using the same diagnostic instrument (the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV) were used to analyze five birth cohorts. Age at initiation of alcohol use, time from first use to dependence, and time from dependence to first treatment were analyzed. Interaction terms (cohort by gender; cohort by gender by time) were tested in Cox proportional hazards models.
Little evidence was found for a telescoping effect in women. For alcohol use and dependence, cohort and gender interacted, which suggests that gender differences are diminished in more recent cohorts. A three-way interaction of cohort, gender, and time was significant for time from first use to dependence, suggesting that men have a shorter time to dependence, especially in younger cohorts.
A telescoping effect is not evident in the general population. Gender differences in the overall hazard of alcohol use and dependence are decreasing in more recent cohorts, while gender differences in time from first use to dependence are increasing. These findings challenge the commonly held notion of a gender-specific course of alcohol disorders and suggest the need for a greater clinical focus on problem drinking in women and further research on accelerated time to dependence in men.
与男性相比,女性的酒精障碍病程通常被描述为“缩短”,表现为饮酒起始年龄较晚,但从开始饮酒到依赖和治疗的时间更短。本研究在一般人群中检验了这种“缩短”效应的证据,并检验了性别差异的出生队列效应。
本研究使用相同的诊断工具(酒精使用障碍和相关障碍访谈表-IV),对两个美国全国性调查的数据进行了分析,这两个调查在 10 年内进行(1991-1992 年和 2001-2002 年)。分析了五个出生队列。分析了饮酒起始年龄、首次饮酒到依赖的时间以及从依赖到首次治疗的时间。在 Cox 比例风险模型中检验了交互项(队列与性别;队列与性别与时间)。
在女性中,几乎没有发现“缩短”效应的证据。对于酒精使用和依赖,队列和性别存在交互作用,这表明在最近的队列中,性别差异在缩小。首次使用到依赖的时间上存在队列、性别和时间的三向交互作用,表明男性依赖的时间更短,尤其是在年轻的队列中。
在一般人群中,没有明显的“缩短”效应。在最近的队列中,酒精使用和依赖的总体风险的性别差异在减少,而从首次使用到依赖的时间上的性别差异在增加。这些发现挑战了关于酒精障碍特定性别病程的普遍观念,并表明需要更加关注女性的问题饮酒,并进一步研究男性依赖时间的加速。