Keyes Katherine M, Grant Bridget F, Hasin Deborah S
New York State Psychiatric Institute, New York, NY 10032, USA.
Drug Alcohol Depend. 2008 Jan 11;93(1-2):21-9. doi: 10.1016/j.drugalcdep.2007.08.017. Epub 2007 Nov 5.
Descriptively, male-female differences in alcohol consumption and alcohol use disorders appear to have decreased in birth cohorts reaching adulthood since the 1970s compared to earlier birth cohorts. However, such birth cohort effects on gender differences have never been statistically tested in nationally representative data. The aim of this study was to test the hypothesis that gender differences in alcohol consumption, abuse, and dependence are decreasing over time.
Face-to-face survey conducted in the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions among those aged <90 (N=42,693). Birth cohort was divided into four categories: 1913-1932, 1933-1949, 1950-1967, 1968-1984. Outcomes included lifetime largest drinks, frequent binge drinking, DSM-IV defined alcohol abuse, and alcohol dependence, measured with the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS-IV).
Birth cohort and gender interacted significantly in predicting lifetime largest drinks (F=27.6, [d.f.=3], p<0.0001), frequent binge drinking (F=40.0, [d.f.=3], p<0.0001), alcohol abuse (F=62.0, [d.f.=3], p<0.0001) and alcohol dependence (F=15.3, [d.f.=3], p<0.0001). Cohort-specific ORs indicated monotonic decreases in the gender ratio in more recent birth cohorts for all outcomes.
These results suggest that gender differences in the prevalence of all four outcomes are decreasing in younger age cohorts. While these changes are consistent with a cohort effect, the possibility of age and period effects cannot be ruled out but suggest important avenues for more specific hypothesis testing. Further, women in younger cohorts may be in need of new targeted prevention and intervention efforts.
从描述上看,与早期出生队列相比,自20世纪70年代以来成年的出生队列中,男性和女性在饮酒及酒精使用障碍方面的差异似乎有所减小。然而,这种出生队列对性别差异的影响从未在具有全国代表性的数据中进行过统计学检验。本研究的目的是检验饮酒、酒精滥用和酒精依赖方面的性别差异是否随时间推移而减小这一假设。
在2001 - 2002年全国酒精及相关状况流行病学调查中,对90岁以下人群(N = 42,693)进行面对面调查。出生队列分为四类:1913 - 1932年、1933 - 1949年、1950 - 1967年、1968 - 1984年。结局指标包括终身最大饮酒量、频繁暴饮、DSM - IV定义的酒精滥用和酒精依赖,通过酒精使用障碍及相关残疾访谈表(AUDADIS - IV)进行测量。
出生队列和性别在预测终身最大饮酒量(F = 27.6,[自由度 = 3],p < 0.0001)、频繁暴饮(F = 40.0,[自由度 = 3],p < 0.0001)、酒精滥用(F = 62.0,[自由度 = 3],p < 0.0001)和酒精依赖(F = 15.3,[自由度 = 3],p < 0.0001)方面存在显著交互作用。特定队列的比值比表明,在所有结局指标上,较近期出生队列中的性别比呈单调下降。
这些结果表明,在较年轻的年龄队列中,所有这四种结局指标的患病率的性别差异正在减小。虽然这些变化与队列效应一致,但年龄和时期效应的可能性不能排除,不过这为更具体的假设检验指明了重要途径。此外,较年轻队列中的女性可能需要新的针对性预防和干预措施。