Lüders H, Lesser R P, Hahn J, Dinner D S, Morris H H, Wyllie E, Godoy J
Department of Neurology, Cleveland Clinic Foundation, Ohio 44195.
Brain. 1991 Apr;114 ( Pt 2):743-54. doi: 10.1093/brain/114.2.743.
Language interference was elicited by electrical stimulation of the dominant basal temporal region in 8 out of 22 cases and in none of 7 cases with subdural electrodes implanted over the nondominant temporal lobe. Language interference was elicited by stimulation of electrodes placed over the fusiform gyrus 3-7 cm from the tip of the temporal lobe. Electrical stimulation of the basal temporal language area produced a global receptive and expressive aphasia with speech arrest at high stimulus intensities. Other higher cortical function, for example copying complex designs or memory of nonverbal information was intact, in spite of the total inability to process verbal information. At lower stimulus intensities partial aphasias with a predominant receptive component occurred. Surgical resection of the basal temporal language area produces no lasting language deficit.
在22例患者中，有8例通过电刺激优势侧颞叶基底区域引发了语言干扰，而在7例将硬膜下电极植入非优势侧颞叶的患者中，无一例出现语言干扰。通过刺激位于距颞叶尖端3 - 7厘米的梭状回上的电极引发了语言干扰。电刺激颞叶基底语言区在高刺激强度下会导致全面的接受性和表达性失语，伴有言语停顿。尽管完全无法处理言语信息，但其他高级皮质功能，如复制复杂图案或记忆非言语信息，仍保持完好。在较低刺激强度下，会出现以接受性成分为主的部分失语。手术切除颞叶基底语言区不会产生持久的语言缺陷。
