Scott Gregory R, Carson Cynthia L, Borah Gregory L
San Diego, Calif.; and New Brunswick, N.J. From the Departments of Plastic Surgery, Kaiser Permanente San Diego Medical Center and Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey.
Plast Reconstr Surg. 2007 Nov;120(6):1460-1465. doi: 10.1097/01.prs.0000282032.05203.8b.
2-Octyl cyanoacrylate (Dermabond; Ethicon, Inc., Somerville, N.J.) has been available as a skin closure alternative or adjunct since 1997. The purpose of this study was to review a large series of 255 consecutive bilateral reduction mammaplasty patients to evaluate the safety and efficacy of Dermabond for these procedures.
A review was undertaken of 255 consecutive bilateral reduction mammaplasties performed by a single surgeon from 1999 to 2005 with Dermabond used for skin closure. This series of patients was compared with an earlier review by the same surgeon of 415 consecutive bilateral reduction mammaplasties using standard layered sutured skin closures.
Dermabond was associated with decreased operative times compared with the sutured closures (93 minutes compared with 118 minutes; 25 minutes or 20 percent less time). The rates for minor wound dehiscence (1.18 percent), major wound dehiscence (0.78), hypertrophic scar revisions (2.75 percent), and cellulitis (2.75 percent) were all lower in the Dermabond group, but these differences were not statistically significant.
Dermabond is a safe and effective means of skin closure for bilateral reduction mammaplasties. Shortened operative times can lead to economic health cost savings. Patient discomfort is minimized and postoperative care is simplified.
自1997年以来，2-辛基氰基丙烯酸酯（皮肤粘合剂；强生公司，新泽西州萨默维尔）一直作为一种皮肤闭合替代方法或辅助方法使用。本研究的目的是回顾一大组连续255例双侧乳房缩小整形术患者，以评估皮肤粘合剂用于这些手术的安全性和有效性。
对1999年至2005年由同一位外科医生进行的连续255例双侧乳房缩小整形术进行回顾，术中使用皮肤粘合剂进行皮肤闭合。将这组患者与该外科医生早期进行的415例连续双侧乳房缩小整形术（使用标准分层缝合皮肤闭合）进行比较。
与缝合闭合相比，使用皮肤粘合剂的手术时间缩短（93分钟对比118分钟；少25分钟或20%的时间）。皮肤粘合剂组的轻微伤口裂开率（1.18%）、严重伤口裂开率（0.78%）、增生性瘢痕修复率（2.75%）和蜂窝织炎发生率（2.75%）均较低，但这些差异无统计学意义。
皮肤粘合剂是双侧乳房缩小整形术安全有效的皮肤闭合方法。缩短手术时间可节省医疗费用。患者不适感降至最低，术后护理也得以简化。
