Berenson M M, Riddell R H, Skinner D B, Freston J W
Cancer. 1978 Feb;41(2):554-61. doi: 10.1002/1097-0142(197802)41:2<554::aid-cncr2820410223>3.0.co;2-v.
This report describes two patients with esophageal columnar epithelium (Barrett's esophagus) in which microinvasive adenocarcinoma developed. Case 1 had multiple foci of carcinoma in situ contiguous with epithelium resembling gastric and intestinal mucosa. Case 2 had signet-ring type adenocarcinoma. Surveillance for malignant transformation in columnar esophageal epithelium should be routinely performed, and because of its focal nature, multiple biopsies and cytologic examination should be carried out. The presence of carcinoma in situ should lead to consideration of excision of the affected esophagus.
本报告描述了两名患有食管柱状上皮（巴雷特食管）并发生微浸润腺癌的患者。病例1有多个原位癌病灶，与类似胃和肠黏膜的上皮相邻。病例2为印戒型腺癌。应常规对食管柱状上皮进行恶变监测，并且由于其病灶的局限性，应进行多次活检和细胞学检查。原位癌的存在应促使考虑切除受影响的食管。
