心肌 Fas 和细胞因子在终末期心力衰竭中的表达：左心室辅助装置的影响。
Myocardial Fas and cytokine expression in end-stage heart failure: impact of LVAD support.
机构信息
Heart Failure/Transplantation Program, Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
出版信息
Clin Transl Sci. 2008 Dec;1(3):245-8. doi: 10.1111/j.1752-8062.2008.00056.x.
Abstract
Left ventricular assist device (LVAD) support may facilitate myocardial recovery. We evaluated the impact of LVAD support on Fas expression in a cohort with end-stage heart failure. Myocardial gene expression was assessed pre- and post-LVAD by RNase protection assay and compared to control donor hearts. The expression of Fas is markedly elevated at the time of LVAD support and is tightly correlated with TNF expression. While interleukin (IL)-6 was significantly reduced by LVAD support, the impact of support on Fas was highly variable and tightly linked to tumor necrosis factor (TNF). The role of Fas in predicting recovery after LVAD support requires further investigation.
摘要
左心室辅助装置（LVAD）支持可能有助于心肌恢复。我们评估了 LVAD 支持对终末期心力衰竭患者 Fas 表达的影响。通过核糖核酸保护测定法在 LVAD 支持前后评估心肌基因表达，并与对照供体心脏进行比较。在 LVAD 支持时，Fas 的表达明显升高，并与 TNF 表达密切相关。虽然白细胞介素（IL）-6 的表达在 LVAD 支持下显著降低，但支持对 Fas 的影响差异很大，与肿瘤坏死因子（TNF）密切相关。Fas 在预测 LVAD 支持后的恢复中的作用需要进一步研究。
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本文引用的文献
1
Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group.
Circulation. 2007 May 15;115(19):2497-505. doi: 10.1161/CIRCULATIONAHA.106.633180. Epub 2007 May 7.
2
Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy.
Eur Heart J. 2007 Mar;28(5):613-27. doi: 10.1093/eurheartj/ehl365. Epub 2006 Nov 28.
3
Left ventricular assist device and drug therapy for the reversal of heart failure.
N Engl J Med. 2006 Nov 2;355(18):1873-84. doi: 10.1056/NEJMoa053063.
4
Myocardial expression of fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy.
J Am Coll Cardiol. 2005 Sep 20;46(6):1036-42. doi: 10.1016/j.jacc.2005.05.067.
5
Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support.
Circulation. 2005 Aug 30;112(9 Suppl):I57-64. doi: 10.1161/CIRCULATIONAHA.104.526137.
6
Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes.
Circulation. 2005 Aug 30;112(9 Suppl):I32-6. doi: 10.1161/CIRCULATIONAHA.104.524124.
7
Apoptosis and heart failure: mechanisms and therapeutic implications.
Am J Cardiovasc Drugs. 2002;2(1):43-57. doi: 10.2165/00129784-200202010-00006.
8
Inflammatory mediators and the failing heart: past, present, and the foreseeable future.
Circ Res. 2002 Nov 29;91(11):988-98. doi: 10.1161/01.res.0000043825.01705.1b.
9
Apoptosis in the cardiovascular system.
Heart. 2002 May;87(5):480-7. doi: 10.1136/heart.87.5.480.
10
Neurohormones, cytokines and programmed cell death in heart failure: a new paradigm for the remodeling heart.
Cardiovasc Drugs Ther. 2001 Nov;15(6):529-37. doi: 10.1023/a:1013771805743.
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