进化：扰动蛋白质功能和网络的指南。
Evolution: a guide to perturb protein function and networks.
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Curr Opin Struct Biol. 2010 Jun;20(3):351-9. doi: 10.1016/j.sbi.2010.04.002. Epub 2010 May 3.
Abstract
Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.
摘要
蛋白质相互作用形成了控制健康和疾病中细胞命运的网络；因此，选择性地探测这些相互作用的方法具有广泛的兴趣。我们在这里讨论进化追踪（Evolutionary Tracing，ET），这是一种识别蛋白质功能位点并指导选择性阻断、重编码或模拟其氨基酸决定因素的实验的比较方法。这些研究原则上表明了一种可扩展的方法，可以干扰蛋白质网络中的个别连接。
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