Jehl J L, Gandmontagne M, Pastene G, Eyssette M, Flandrois R, Coudert J
Laboratoire de physiologie, Faculté de Médecine, Clermont-Ferrand, France.
Eur J Appl Physiol Occup Physiol. 1991;62(4):256-60. doi: 10.1007/BF00571549.
The purpose of this study was to measure the cardiac output using the CO2 rebreathing method during submaximal and maximal arm cranking exercise in six male paraplegic subjects with a high level of spinal cord injury (HP). They were compared with eight able bodied subjects (AB) who were not trained in arm exercise. Maximal O2 consumption (VO2max) was lower in HP (1.11.min, SD 0.1; 17.5 ml.min-1.kg-1, SD 4) than in AB (2.5 l.min-1, SD 0.6; 36.7 ml.min-1.kg, SD 10.7). Maximal cardiac output was similar in the groups (HP, 14 l.min-1, SD 2.6; AB, 16.8 l.min-1, SD 4). The same result was obtained for maximal heart rate (fc,max) (HP, 175 beats.min-1, SD 18; AB, 187 beats.min-1, SD 16) and the maximal stroke volume (HP, 82 ml, SD 13; AB, 91 ml, SD 27). The slopes of the relationship fc/VO2 were higher in HP than AB (P less than 0.025) but when expressed as a %VO2max there were no differences. The results suggest a major alteration of oxygen transport capacity to active muscle mass in paraplegics due to changes in vasomotor regulation below the level of the lesion.
本研究的目的是采用二氧化碳重呼吸法，测量6名高位脊髓损伤（HP）男性截瘫患者在次最大和最大强度手臂曲柄运动期间的心输出量。将他们与8名未接受过手臂运动训练的健全受试者（AB）进行比较。HP组的最大耗氧量（VO2max）低于AB组（HP组：1.11升/分钟，标准差0.1；17.5毫升/分钟·千克，标准差4；AB组：2.5升/分钟，标准差0.6；36.7毫升/分钟·千克，标准差10.7）。两组的最大心输出量相似（HP组：14升/分钟，标准差2.6；AB组：16.8升/分钟，标准差4）。最大心率（fc,max）（HP组：175次/分钟，标准差18；AB组：187次/分钟，标准差16）和最大每搏输出量（HP组：82毫升，标准差13；AB组：91毫升，标准差27）也得到相同结果。HP组fc/VO2关系的斜率高于AB组（P<0.025），但以最大耗氧量百分比表示时则无差异。结果表明，由于损伤平面以下血管运动调节的改变，截瘫患者向活动肌肉群输送氧气的能力发生了重大改变。
