Link Nancy J, Maurer Eva, Largent Joan, Kent Erin, Morris Rebecca A, Sender Leonard S, Anton-Culver Hoda
Department of Epidemiology, School of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697, USA.
J Cancer Epidemiol. 2009;2009:354257. doi: 10.1155/2009/354257. Epub 2010 Feb 10.
Advances have been made in treatment and outcomes for pediatric cancer. However adolescents and young adults (AYAs) with cancer have not experienced similar relative improvements. We undertook a study to develop the methodology necessary for epidemiologic cancer research in these age groups. Our goal was to create the Kids, Adolescents, and Young Adults Cancer (KAYAC) project to create a resource to address research questions relevant to this population. We used a combination of clinic and population-based ascertainment to enroll 111 cases aged 0-39 for this methodology development study. The largest groups of cancer types enrolled include: breast cancer, leukemia, lymphoma, and melanoma. The overall participation rate is 69.8% and varies by age and tumor type. The study included patients, mothers, and fathers. The methods used to establish this resource are described, and the values of the resource in studies of childhood and young adult cancer are outlined.
儿童癌症的治疗和预后已取得进展。然而，患有癌症的青少年和青年（AYAs）并未经历类似的相对改善。我们开展了一项研究，以开发这些年龄组癌症流行病学研究所需的方法。我们的目标是创建儿童、青少年和青年癌症（KAYAC）项目，以创建一个资源来解决与该人群相关的研究问题。我们采用临床和基于人群的确诊相结合的方法，为这项方法开发研究招募了111例年龄在0至39岁之间的病例。登记的最大癌症类型组包括：乳腺癌、白血病、淋巴瘤和黑色素瘤。总体参与率为69.8%，并因年龄和肿瘤类型而异。该研究纳入了患者、母亲和父亲。描述了用于建立该资源的方法，并概述了该资源在儿童和青年癌症研究中的价值。
