Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, 6116 Executive Blvd, Bethesda, MD 20892, USA.
Qual Life Res. 2013 Aug;22(6):1339-51. doi: 10.1007/s11136-012-0254-z. Epub 2012 Aug 26.
Cancer registry survival analyses have shown that adolescent and young adult patients with low socioeconomic status (SES) have reduced survival compared to those with higher SES. The objective of this study was to determine whether neighborhood- (nSES) and/or individual-level SES (iSES) also predicted current quality of life in adolescent and young adult survivors.
The Socioeconomics and Quality of Life study surveyed adolescent and young adult survivors of leukemia and lymphoma at least one year post-diagnosis using population-based ascertainment. Factor analysis was used to create a multidimensional age-relevant iSES score and compared with a preexisting census-block-group derived nSES score. Four quality of life domains were assessed: physical health, psychological and emotional well-being, social relationships, and life skills. Nested multivariable linear regression models were run to test the associations between both SES measures and quality of life and to compare the explanatory power of nSES and iSES.
Data from 110 individuals aged 16-40 were included in the final analysis. After adjustment for sociodemographic confounders, low nSES was associated only with poorer physical health, whereas low iSES was related to poorer quality of life in all four domains with iSES accounting for an additional 14, 12, 25, and 10 % of the variance, respectively.
Measures of SES at the individual as compared to the neighborhood level may be stronger indicators of outcomes in adolescents and young adults, which has important implications for SES measurement in the context of cancer surveillance.
癌症登记处的生存分析表明，社会经济地位（SES）较低的青少年和年轻成年癌症患者的生存率低于 SES 较高的患者。本研究的目的是确定邻里（nSES）和/或个体 SES（iSES）是否也预测青少年和年轻成年癌症幸存者的当前生活质量。
使用基于人群的确定方法，对至少在诊断后一年的白血病和淋巴瘤青少年和年轻成年幸存者进行了社会经济学和生活质量研究调查。使用因子分析创建了多维与年龄相关的 iSES 评分，并与预先存在的普查街区组衍生的 nSES 评分进行了比较。评估了四个生活质量领域：身体健康、心理和情绪健康、社会关系和生活技能。进行嵌套多变量线性回归模型以测试这两种 SES 措施与生活质量之间的关联，并比较 nSES 和 iSES 的解释能力。
最终分析包括 110 名年龄在 16-40 岁的个体的数据。在校正了社会人口统计学混杂因素后，低 nSES 仅与较差的身体健康相关，而低 iSES 与所有四个领域的较差生活质量相关，iSES 分别解释了 14%、12%、25%和 10%的差异。
与邻里水平相比，个体 SES 衡量标准可能是青少年和年轻成年人结局的更强指标，这对癌症监测背景下 SES 衡量标准具有重要意义。
