Organic Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
J Org Chem. 2010 Jun 4;75(11):3916-9. doi: 10.1021/jo1005813.
Oxidative allylation to sp(2)- and sp(3)-carbon attached to the nitrogen atom was accomplished. The alpha-allylation of tertiary amines was catalyzed by easily available hydrated iron(III) chloride in combination with air or aqueous (t)BuOOH. Remarkably, N-allyl- and N-propagyl-tethered tertiary amines were also allylated through this protocol.
实现了氮原子上连接的 sp(2)-和 sp(3)-碳的氧化烯丙基化反应。三乙胺的 α-烯丙基化反应可以在易获得的水合三氯化铁与空气或水相 (t)BuOOH 的组合催化下进行。值得注意的是，通过该方案还可以对 N-烯丙基-和 N-丙基键合的叔胺进行烯丙基化。
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