Chest physiotherapy in hospitalized patients with cystic fibrosis: a study of lung function effects and sputum production.

In order to evaluate the short-term lung function effects of high-pressure positive expiratory pressure (PEP)-mask physiotherapy (PT) in relation to PT-assisted sputum production, we studied 18 patients with cystic fibrosis (CF), hospitalized for a pulmonary exacerbation. Lung functions were measured before (a) and after PT (b) on day one (1), five (2), ten (3) and fifteen (4). Five functions improved significantly from a1 to b1, eight from a2 to b2, seven from a3 to b3, and seven from a4 to b4. Baseline (a) measurements improved only slightly, but post-PT (b) values improved more markedly from 1 to 4, and this improvement reached statistical significance for six functions; consequently, a-to-b lung function changes tended to increase from investigation 1 to 4. Eleven PT-induced lung function changes correlated to the weight of sputum produced. High-pressure PEP-mask PT therefore resulted in significant lung function improvements, and not only maintained but increased its effect in the course of the hospitalization.