Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Room D517, O Block, Victoria Park Road, Kelvin Grove, 4059 Brisbane, Queensland, Australia.
Exp Eye Res. 2010 Aug;91(2):180-5. doi: 10.1016/j.exer.2010.04.015. Epub 2010 May 4.
This study aimed to investigate the influence of water loading upon intraocular pressure (IOP), ocular pulse amplitude (OPA) and axial length. Twenty-one young adult subjects who were classified based on their spherical equivalent refraction as either myopes (n = 11), or emmetropes (n = 10) participated. Measures of IOP, OPA and ocular biometrics were collected before, and then 10, 15, 25 and 30 min following the ingestion of 1000 ml of water. Significant increases in both IOP and OPA were found to occur following water loading (p < 0.0001), with peaks in both parameters occurring at 10 min after water loading (mean +/- SEM increase of 2.24 +/- 0.31 mmHg in IOP and 0.46 +/- 0.06 mmHg in OPA). Axial length was found to reduce significantly following water loading (p = 0.0005), with the largest reduction in axial length evident 10 min after water drinking (mean decrease 12 +/- 3 microm). A significant time by refractive error group interaction (p = 0.048) was found in axial length, indicative of a different pattern of change in eye length following water loading between the myopic and emmetropic populations. The largest difference in axial length change was evident at 10 min after water loading with a 17 +/- 5 microm reduction in axial length evident in the myopes and only a 6 +/- 2 microm reduction in the emmetropes. These findings illustrate significant changes in ocular parameters in young adult subjects following water loading.
本研究旨在探讨水负荷对眼内压（IOP）、眼脉冲幅度（OPA）和眼轴长度的影响。21 名年轻成年受试者根据等效球镜屈光度分为近视组（n=11）和正视组（n=10）。在饮水 1000ml 前后分别测量了 IOP、OPA 和眼部生物测量值。结果发现，水负荷后 IOP 和 OPA 均显著升高（p<0.0001），水负荷后 10 分钟时这两个参数均达到峰值（IOP 平均增加 2.24±0.31mmHg，OPA 平均增加 0.46±0.06mmHg）。水负荷后眼轴长度显著缩短（p=0.0005），水负荷后 10 分钟时眼轴长度缩短最明显（平均减少 12±3μm）。眼轴长度的时间与屈光不正组之间存在显著的交互作用（p=0.048），表明近视和正视人群在水负荷后眼轴长度的变化模式不同。水负荷后 10 分钟时，眼轴长度的变化差异最大，近视组眼轴长度减少 17±5μm，而正视组仅减少 6±2μm。这些发现表明，水负荷后年轻成年受试者的眼部参数发生了显著变化。
