Department of Ophthalmology, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Jpn J Ophthalmol. 2012 Nov;56(6):564-8. doi: 10.1007/s10384-012-0173-0. Epub 2012 Aug 11.
To measure changes in choroidal thickness (CT), retinal thickness (RT), and axial length (AL) accompanying intraocular pressure (IOP) increase and to investigate the changes in axial eye dimensions induced by IOP increase.
Thirty-four eyes of 34 patients undergoing a diagnostic provocative test for primary angle closure (PAC). Patients with other macular diseases were excluded. Patients underwent the darkroom prone provocative test (DR-PPT) for 1 h. We measured CT and RT at the fovea by optical coherence tomography with the enhanced depth imaging method and AL with noncontact, partial coherence laser interferometry before and after the DR-PPT.
There was a statistically significant increase in the mean (SD) IOP of 7.3 (9.2) mmHg and the mean (SD) AL of 0.06 (0.12) mm after the DR-PPT (P < 0.001 and P = 0.014, respectively). There was a statistically significant decrease in the mean (SD) subfoveal CT of 30.0 (36.8) μm (P < 0.001), while there was no significant change in the mean foveal RT. The change in subfoveal CT was negatively correlated with the changes in IOP (r = -0.71, P < 0.001) and AL (r = -0.54, P = 0.004).
In eyes suspected of having PAC, acutely increased IOP accompanies choroid thinning and corresponding elongation of the optical axis.
测量伴随眼压（IOP）升高的脉络膜厚度（CT）、视网膜厚度（RT）和眼轴长度（AL）的变化，并研究由IOP 升高引起的眼轴尺寸的变化。
34 例疑似原发性闭角型青光眼（PAC）患者的 34 只眼。排除其他黄斑疾病患者。患者接受暗室俯卧位激发试验（DR-PPT）1 小时。在 DR-PPT 前后，我们使用增强深度成像法的光学相干断层扫描测量黄斑中心凹的 CT 和 RT，使用非接触式部分相干激光干涉仪测量 AL。
DR-PPT 后，平均（标准差）IOP 升高 7.3（9.2）mmHg，平均（标准差）AL 增加 0.06（0.12）mm，差异均有统计学意义（P<0.001 和 P=0.014）。黄斑中心凹下 CT 平均（标准差）下降 30.0（36.8）μm，差异有统计学意义（P<0.001），而黄斑中心凹 RT 无明显变化。黄斑中心凹下 CT 的变化与 IOP（r=-0.71，P<0.001）和 AL（r=-0.54，P=0.004）的变化呈负相关。
在疑似 PAC 的眼中，急性升高的 IOP 伴随着脉络膜变薄和光轴相应伸长。
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