Medicine. Beige can be slimming.
作者信息
Ishibashi Jeff, Seale Patrick
机构信息
Institute for Diabetes, Obesity and Metabolism and the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
Science. 2010 May 28;328(5982):1113-4. doi: 10.1126/science.1190816. Epub 2010 May 6.
Abstract
摘要
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Medicine. Beige can be slimming.医学。米色有显瘦效果。
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本文引用的文献
1
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.健康成年人中代谢活跃的棕色脂肪组织发生率高：寒冷暴露和肥胖的影响。
Diabetes. 2009 Jul;58(7):1526-31. doi: 10.2337/db09-0530. Epub 2009 Apr 28.
2
Functional brown adipose tissue in healthy adults.健康成年人中的功能性棕色脂肪组织。
N Engl J Med. 2009 Apr 9;360(15):1518-25. doi: 10.1056/NEJMoa0808949.
3
Identification and importance of brown adipose tissue in adult humans.成人棕色脂肪组织的识别及其重要性。
N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.
4
Cold-activated brown adipose tissue in healthy men.健康男性体内的冷激活棕色脂肪组织
N Engl J Med. 2009 Apr 9;360(15):1500-8. doi: 10.1056/NEJMoa0808718.
5
Transcriptional control of brown adipocyte development and physiological function--of mice and men.棕色脂肪细胞发育和生理功能的转录调控——小鼠与人的研究
Genes Dev. 2009 Apr 1;23(7):788-97. doi: 10.1101/gad.1779209.
6
PRDM16 controls a brown fat/skeletal muscle switch.PRDM16控制棕色脂肪/骨骼肌转换。
Nature. 2008 Aug 21;454(7207):961-7. doi: 10.1038/nature07182.
7
Prostaglandin E receptors.前列腺素E受体
J Biol Chem. 2007 Apr 20;282(16):11613-7. doi: 10.1074/jbc.R600038200. Epub 2007 Feb 28.
8
beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.β3-肾上腺素能受体激动剂：潜力、陷阱与进展
Eur J Pharmacol. 2002 Apr 12;440(2-3):99-107. doi: 10.1016/s0014-2999(02)01421-8.
9
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.复杂的信号：前列腺素和血栓素对炎症和免疫反应的调节
J Clin Invest. 2001 Jul;108(1):15-23. doi: 10.1172/JCI13416.
10
Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.腹腔注射前列腺素E2可减轻大鼠因束缚或白细胞介素-1诱导的体温过高。
J Physiol. 1991 Dec;444:363-73. doi: 10.1113/jphysiol.1991.sp018883.
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