住院婴儿呼吸道合胞病毒阳性细支气管炎与血小板增多症相关。

Respiratory syncytial virus-positive bronchiolitis in hospitalized infants is associated with thrombocytosis.

作者信息

Bilavsky Efraim, Yarden-Bilavsky Havatzelet, Shouval Dror S, Fisch Naama, Garty Ben-Zion, Ashkenazi Shai, Amir Jacob

机构信息

Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.

出版信息

Isr Med Assoc J. 2010 Jan;12(1):39-41.

PMID:20450128

Abstract

BACKGROUND

Secondary thrombocytosis is associated with a variety of clinical conditions, one of which is lower respiratory tract infection. However, reports on thrombocytosis induced by viral infections are scarce.

OBJECTIVES

To assess the rate of thrombocytosis (platelet count > 500 x 10(9)/L) in hospitalized infants with bronchiolitis and to investigate its potential role as an early marker of respiratory syncytial virus infection.

METHODS

Clinical data on 469 infants aged < or = 4 months who were hospitalized for bronchiolitis were collected prospectively and compared between RSV-positive and RSV-negative infants.

RESULTS

The rate of thrombocytosis was significantly higher in RSV-positive than RSV-negative infants (41.3% vs. 29.2%, P=0.031). The odds ratio of an infant with bronchiolitis and thrombocytosis to have a positive RSV infection compared to an infant with bronchiolitis and a normal platelet count was 1.7 (P= 0.023, 95% confidence interval 1.07-2.72). There was no significant difference in mean platelet count between the two groups.

CONCLUSIONS

RSV-positive bronchiolitis in hospitalized young infants is associated with thrombocytosis.

摘要

背景

继发性血小板增多症与多种临床病症相关，其中之一是下呼吸道感染。然而，关于病毒感染所致血小板增多症的报道较少。

目的

评估住院毛细支气管炎婴儿的血小板增多症（血小板计数>500×10⁹/L）发生率，并探讨其作为呼吸道合胞病毒感染早期标志物的潜在作用。

方法

前瞻性收集469例年龄≤4个月因毛细支气管炎住院婴儿的临床资料，并在呼吸道合胞病毒阳性和阴性婴儿之间进行比较。

结果

呼吸道合胞病毒阳性婴儿的血小板增多症发生率显著高于呼吸道合胞病毒阴性婴儿（41.3%对29.2%，P = 0.031）。与毛细支气管炎且血小板计数正常的婴儿相比，毛细支气管炎且血小板增多症的婴儿发生呼吸道合胞病毒感染阳性的比值比为1.7（P = 0.023，95%置信区间1.07 - 2.72）。两组之间的平均血小板计数无显著差异。