Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, India.
Cardiovasc Toxicol. 2010 Sep;10(3):181-9. doi: 10.1007/s12012-010-9077-8.
Consumption of diets rich in flavonoids is associated with reduced risk of cardiovascular diseases such as myocardial infarction. Cardiotoxicity was induced in rats by subcutaneous injection of isoproterenol at an interval of 24 h for 2 days. Isoproterenol-induced rats showed a significant increase in the levels of heart mitochondrial lipids, lipid peroxidation products, calcium and a significant decrease in the activities/levels of mitochondrial antioxidants, enzymes and adenosine triphosphate. Isoproterenol-induced rats also showed an increase in the intensities of serum lactate dehydrogenase-1 and 2 isoenzyme bands. Pretreatment with rutin at the dose of 80 mg/kg daily for 42 days to isoproterenol-induced rats prevented all the biochemical alterations. Transmission electron microscopic study also confirmed the protective effects of rutin on the structure of heart mitochondria. Thus, rutin reduced the extent of mitochondrial damage induced by isoproterenol and prevented cardiac mitochondrial dysfunction. The possible mechanisms for the observed effects of rutin could be due to scavenging free radicals, lowering lipid peroxides, lipids and calcium, improving multienzyme activities, glutathione levels, adenosine triphosphate levels, thereby improving cardiac mitochondrial structure and function. This study may have a significant impact on myocardial infarcted patients.
食用富含类黄酮的饮食与降低心血管疾病（如心肌梗死）的风险有关。通过皮下注射异丙肾上腺素，在 2 天内每隔 24 小时注射一次，在大鼠中诱导心脏毒性。异丙肾上腺素诱导的大鼠心脏线粒体脂质、脂质过氧化产物、钙水平显著升高，线粒体抗氧化剂、酶和三磷酸腺苷的活性/水平显著降低。异丙肾上腺素诱导的大鼠血清乳酸脱氢酶-1 和 2 同工酶带的强度也增加。用 80mg/kg 剂量的芦丁预处理 42 天，可预防异丙肾上腺素引起的所有生化改变。透射电子显微镜研究也证实了芦丁对心脏线粒体结构的保护作用。因此，芦丁减轻了异丙肾上腺素引起的线粒体损伤程度，并预防了心脏线粒体功能障碍。芦丁观察到的作用的可能机制是由于清除自由基、降低脂质过氧化物、脂质和钙、提高多种酶的活性、谷胱甘肽水平、三磷酸腺苷水平，从而改善心脏线粒体的结构和功能。这项研究可能对心肌梗死患者有重大影响。
