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Nano-biotechnology: carbon nanofibres as improved neural and orthopaedic implants.纳米生物技术:作为改良神经和骨科植入物的碳纳米纤维
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Conducting-Polymer Nanotubes for Controlled Drug Release.用于可控药物释放的导电聚合物纳米管
Adv Mater. 2006 Feb 17;18(4):405-409. doi: 10.1002/adma.200501726.
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Chemically Functionalized Carbon Nanotubes as Substrates for Neuronal Growth.化学功能化碳纳米管作为神经元生长的基质
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Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology.纳米技术和纳米医学的安全性评估:纳米毒理学概念。
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Toxicity issues in the application of carbon nanotubes to biological systems.碳纳米管在生物系统应用中的毒性问题。
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Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes.羧化单壁碳纳米管抑制人骨形态发生蛋白信号通路。
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Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.利用表皮生长因子(EGF)导向的基于碳纳米管的药物递送在体内和体外对癌细胞进行靶向杀伤。
ACS Nano. 2009 Feb 24;3(2):307-16. doi: 10.1021/nn800551s.
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Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery.用于药物负载与递送的水溶性碳纳米管上的超分子化学
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Selective uptake of multi-walled carbon nanotubes by tumor macrophages in a murine glioma model.在小鼠胶质瘤模型中肿瘤巨噬细胞对多壁碳纳米管的选择性摄取
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功能化碳纳米管在潜在医学应用中的研究进展

Functionalized carbon nanotubes for potential medicinal applications.

机构信息

School of Pharmaceutical Sciences, Shandong University, Jinan, 250100, China.

出版信息

Drug Discov Today. 2010 Jun;15(11-12):428-35. doi: 10.1016/j.drudis.2010.04.005. Epub 2010 May 6.

DOI:10.1016/j.drudis.2010.04.005
PMID:20451656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4830352/
Abstract

Functionalized carbon nanotubes display unique properties that enable a variety of medicinal applications, including the diagnosis and treatment of cancer, infectious diseases and central nervous system disorders, and applications in tissue engineering. These potential applications are particularly encouraged by their ability to penetrate biological membranes and relatively low toxicity. High aspect ratio, unique optical property and the likeness as small molecule make carbon nanotubes an unusual allotrope of element carbon. After functionalization, carbon nanotubes display potentials for a variety of medicinal applications, including the diagnosis and treatment of cancer, infectious diseases and central nervous system disorders, and applications in tissue engineering. These potential applications are particularly encouraged by their ability to penetrate biological membranes and relatively low toxicity.

摘要

功能化碳纳米管具有独特的性质,使其在医学领域有多种应用,包括癌症、传染病和中枢神经系统疾病的诊断和治疗,以及在组织工程中的应用。其能够穿透生物膜和相对较低的毒性,这使得这些潜在应用尤其受到鼓励。高纵横比、独特的光学特性和小分子的相似性使碳纳米管成为碳元素的一种不寻常的同素异形体。经过功能化处理后,碳纳米管在多种医学应用中具有潜力,包括癌症、传染病和中枢神经系统疾病的诊断和治疗,以及在组织工程中的应用。其能够穿透生物膜和相对较低的毒性,这使得这些潜在应用尤其受到鼓励。